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Oxford Centre for Tropical Medicine and Global Health

Professor Sir Nicholas White OBE KCMG FRS

The Centre for Tropical Medicine and Global Health, the University of Oxford and the Nuffield Department of Medicine greatly mourn the death of Professor Sir Nicholas White, a distinguished clinician and scientist who was internationally recognised as the leading figure in improving the treatment of malaria worldwide, and whose work has made a lasting contribution to global health research - saving millions of lives worldwide. Our thoughts are with his family at this time.

OUCRU & the Hospital for Tropical Diseases: 35 years of partnership

From our earliest malaria trials in 1991 to today’s shared work on many infectious diseases, OUCRU marks 35 years of partnership with the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam, advancing research that improves patient care and strengthens responses to infectious diseases. Rooted in frontline clinical collaboration, OUCRU continues to drive evidence-based innovations, build local research capacity, and address evolving health challenges across Vietnam and the region.

“AMR Ambassador” Competition: When Students Become Voices Against Antimicrobial Resistance

The OUCRU Hanoi Research Team and the PCE team, in collaboration with the Students’ Clinical Pharmacy Club, Hanoi University of Pharmacy successfully conducted the AMR Ambassador Competition on Monday, 12 January 2026, at Kim Lien High School, Hanoi.

OUCRU’s LAST ACT trial explores personalised treatment for tuberculous meningitis

OUCRU’s LAST ACT trial, published in Nature Medicine, is the first tuberculosis study to assess treatment based on host genetics. The trial tested whether dexamethasone could be withheld in patients with low- or medium-inflammatory LTA4H genotypes. Results showed no evidence that placebo was as effective as dexamethasone, which remained safe and modestly effective across genotypes. These findings support continued use of dexamethasone and highlight the need for better-targeted treatments for tuberculous meningitis.

Building Lasting Impact: Professor Guy Thwaites’ Legacy at OUCRU

Over more than a decade of leadership, Professor Guy Thwaites helped steer the Oxford University Clinical Research Unit through a period of strategic growth and increasing global relevance. Under his direction, OUCRU strengthened its focus on research driven by clinical need, expanded its regional footprint, and deepened its contribution to tackling some of the most pressing infectious disease challenges in Southeast Asia and beyond.

International collaboration launches largest-ever therapeutics trial for patients hospitalised with dengue

A landmark international research collaboration has launched the largest clinical trial ever conducted to test therapeutics for moderate-severe dengue, a mosquito-borne viral disease that continues to spread rapidly driven by climate change and globalisation.

OUCRU trials AI-powered wearables for early warning of severe dengue

AI applications in dengue monitoring and prediction are showing encouraging early signals, with new models achieving around 80% accuracy in forecasting severe progression up to two hours in advance. The Oxford University Clinical Research Unit (OUCRU) presented these findings at the Dengue Summit 2025, organised by Ho Chi Minh City Pasteur Institute.

Community Engagement in Antimicrobial Stewardship Programmes Implementation – 60HN ASPARNet

The study titled “Evaluating Antimicrobial Stewardship strategies and capacity building through Participatory Action Research and a Network approach in Vietnam” (60HN – ASPARNet) continues to implement activities to promote Antimicrobial Stewardship (AMS) programmes across hospitals participating in the network.

Youth Peer Educator Combat AMR: Indonesian Youth Action in Antimicrobial Resistance’s Stewardship

Knowledge and beliefs about antibiotics continue to shape emerging health behaviours in Indonesia. With support from OUCRU, PAPRA empowered young people to create learning resources to promote responsible antibiotic use among their peers.

Communicate Antimicrobial resistance (AMR) using community-based, co-created media

World AMR Awareness Week (18–24 November) promotes global action against antimicrobial resistance (AMR) under the theme “Act Now: Protect Our Present, Secure Our Future.” Vietnam, among the countries with the highest antibiotic resistance rates, faces widespread antibiotic misuse. OUCRU and partners have launched innovative, youth-focused engagement initiatives—including animated videos, theatre performances, and peer-led projects in Vietnam, Indonesia, and Nepal—to raise awareness, correct misconceptions, and connect science with everyday experiences.

Study Finds COVID-19 Vaccine Boosters Still Protect Vulnerable Indonesians Well Into the Post-Pandemic Period

COVID-19 vaccine booster shots made from the original strain of the virus still save lives among vulnerable Indonesians, but provide limited protection for the wider public, according to a new study by OUCRU Indonesia, Universitas Gadjah Mada, and the U.S. Centers for Disease Control and Prevention.

Bridging the community voices: OUCRU Indonesia held the Kick-Off Meeting Community Forum for Health Research (ForuM)

In September, OUCRU Indonesia held the kick-off meeting of the Community Forum for Health Research (ForuM) — an initiative that connect OUCRU Indonesia researchers with lay public to strengthen OUCRU research and community engagement. The ForuM serves as OUCRU Indonesia’s Community Advisory Group (CAG) — a mechanism for two-way communication between researchers and the public. Members shared advice, guidance and feedback on study design, recruitment strategies, informed consent materials, cultural appropriateness, ethical considerations, and the communication of research findings.

MODRA Cohort 2: From ideas to action

Following the success of the first MODRA workshop in September, where participants developed strong research grant proposals, the MODRA Cohort 2 researchers reconvened at OUCRU Ho Chi Minh City for Workshop 2, focused on taking their projects from paper to practice.

OUCRU supports new WHO report tracking global antimicrobial resistance

The World Health Organization (WHO) has released its 2025 Global Antimicrobial Resistance and Use Surveillance (GLASS) Report, offering the most comprehensive global data on antimicrobial resistance (AMR) to date. Among the contributors were OUCRU Indonesia’s Professor Raph Hamers and Dr Gilbert Lazarus, whose systematic reviews provided critical insights into resistance trends. Their findings highlight rising resistance, especially in low-resource settings, and underscore the need for stronger surveillance and evidence-informed policy to address this growing health threat.

At the Frontline of Infectious Diseases: My Experience as a Clinical Intern from Germany at OUCRU

German medical student Du Hanh spent a month at the Oxford University Clinical Research Unit (OUCRU) in Ho Chi Minh City, gaining firsthand experience in tropical and infectious diseases. From ICU rounds to research discussions, he discovered how OUCRU connects clinical care, research, and public health to make a real-world impact.

OUCRU Nepal and A*STAR IDL Sign MoU

OUCRU Nepal has officially signed a Memorandum of Understanding with the A*STAR Infectious Diseases Labs (A*STAR IDL), Singapore, to establish a collaborative partnership aimed at advancing research in infectious diseases. This strategic collaboration focuses on mutual interest with a shared focus on antimicrobial resistance, respiratory diseases, and vector-borne diseases, including associated neuroviral outcomes.

Sabina Dongol Selected for ISARIC Leadership Programme for Scientists

OUCRU-Nepal is proud to announce that Dr Sabina Dongol has been selected to join the first cohort of the ISARIC Leadership Programme for Scientists a global initiative aimed at empowering mid-career female researchers from Low- and Middle-Income Countries (LMICs) to become independent research leaders.

OUCRU contributes to defining the first core outcome measurement set for Dengue

A major international collaboration between ISARIC researchers at King’s College London and the Oxford University Clinical Research Trials Unit (OUCRU) has created the first global Core Outcome Measurement Set (COMS) for dengue clinical trials.

OUCRU workshop drives dialogue on early warning systems for climate-sensitive infectious diseases

Researchers, policymakers, and health professionals gathered at the Oxford University Clinical Research Unit (OUCRU) for a workshop on “Enablers and Barriers to Development and Implementation of Early Warning and Response Systems for Climate-Sensitive Infectious Diseases in Viet Nam.”

Building Vietnam’s Clinical Trial Future: OUCRU and Partners at the Forefront

On 26 September 2025, leading researchers, policymakers, and international partners gathered in Hanoi for the Workshop on Clinical Trial Opportunities in Viet Nam, co-organised by the World Health Organization, Hanoi Medical University, and the Oxford University Clinical Research Unit (OUCRU). The event marked an important step in strengthening Vietnam’s clinical trial ecosystem, aligning national ambitions with global health innovation.

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