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On Tues 6 June 2017, researchers vaccinated volunteers and began Mahidol University’s study of the malaria vaccine RTS,S/AS01. This is the first study in Asia of the vaccine, an advanced product that has received regulatory approval in Europe.
Incorporating acute HIV infection screening, same-day diagnosis and antiretroviral treatment into routine services for key populations at sexual health clinics in Indonesia: a baseline analysis of the INTERACT prospective study
Posted 02/05/2025. In the INTERACT study, Raph Hamers and collaborators successfully implemented “test-and-immediately-treat” services for persons with acute HIV infection (AHI) at sexual health clinics in Jakarta and Bali. AHI screening at scale offers the potential for enhanced interventions to achieve the full population benefits of “treat-all” strategies and curb the escalated HIV epidemic among key populations in Indonesia.
Defining the noma research agenda
Posted 30/04/2025. The results from a September 2024 symposium on Defining the Noma Research Agenda at the Swiss Tropical and Public Health Institute has identified research needs and the way forward. The symposium included noma survivors as well as clinical and epidemiological researchers, and follows the WHO’s official recognition of noma as a neglected tropical disease. By Philippe Guerin.
Creating different global health futures: mapping the health research ecosystem and taking decolonial action
Posted 29/04/2025. Decolonisation in global health emphasises the need to challenge and change entrenched power asymmetries and unfair health research practices. Nadia Tagoe, Sassy Molyneux, Caesar Atuire and colleagues have proposed practical decolonial action using a four-step framework and a reflexive tool that can help transform key domains of the global health knowledge ecosystem.
Effect of a novel house design (star home) on indoor malaria mosquito abundance in rural Tanzania: secondary outcomes of an open-label, household, randomised controlled trial
Posted 23/04/2025. A novel screened house design with bedrooms on the second storey reduced indoor mosquito abundance (51% less Anopheles gambiae; 61% less Culex species) and were 0·5°C cooler compared with traditional houses in Mtwara, Tanzania. By Lorenz Von Seidlein
Putting health facilities on the map: a renewed call to create geolocated, comprehensive, updated, openly licensed dataset of health facilities in sub-Saharan African countries
Posted 15/04/2025. Healthcare service provision and planning depend on the availability of a comprehensive health facility database (HFDB) to adequately meet the healthcare needs of a population. However, the availability of HFDBs has remained a big challenge in sub-Saharan Africa (SSA). Peter Macharia and colleagues elaborate historical developments and the current status of HFDBS while describing the steps required and challenges to overcome for harmonized SSA-wide HFDBs.
Call for a fairer approach to authorship in publishing biomedical research
Posted 11/04/2025. Phaik Yeong Cheah and Michael Parker advocate for fairer authorship in collaborative biomedical research to enhance equity and inclusiveness. They highlight how current practices overlook contributors and discuss challenges in authorship decisions, including project size, multidisciplinary complexity, and the varied roles of researchers at different stages.
Longitudinal tracking of healthcare professionals: a methodological scoping review
Posted 09/04/2025. How do health workers move through their careers - and how do we know? A new scoping review led by Yingxi Zhao and colleagues examined 263 studies tracking healthcare professionals over time, exploring how career choices, working conditions and wellbeing are measured. The review highlights the need for stronger, standardised tracking methods to inform workforce planning and better support health worker wellbeing across contexts.
Situational analysis of antibiotic prescriptions in Kenyan neonatal units for antimicrobial stewardship: a retrospective longitudinal study
Posted 08/04/2025. High antibiotic use in Kenyan neonatal units may contribute to antimicrobial resistance. A study of 88,000 neonatal admissions in 22 hospitals found 62.6% received antibiotics at admission, mostly first-line drugs. However, non-first-line use was higher in outborn neonates. Monitoring antibiotic patterns at scale feasible and crucial for assessing antimicrobial stewardship and reducing resistance. With Jalemba Aluvaala and Mike English
Strengthening the paediatric clinical trial ecosystem to better inform policy and programmes
Posted 04/04/2025. The first WHO Global Clinical Trials Forum was convened in November 2023 to develop a shared vision of an effective global clinical trial infrastructure. In this paper, the Paediatric Clinical Trials Working Group shares perspectives, identify challenges, and proposes solutions to strengthen the global paediatric clinical trials ecosystem. By James Berkley
Reducing global inequities in medical oxygen access: the Lancet Global Health Commission on medical oxygen security
Posted 01/04/2025. Medical oxygen is a critical treatment in severe illness, yet global access remains inequitable, especially in low-income countries. The COVID-19 pandemic highlighted these disparities. The Lancet Global Health Commission emphasizes systemic improvements, investments in infrastructure, workforce training, and affordability. Addressing these gaps can save millions of lives and strengthen global health resilience. With Jacquie Oliwa and Mike English as members of this Lancet Commission.
Effects of health system limitations on the use of blood culture and sensitivity testing in Kenyan county hospitals: an interview-based qualitative study using causal loop diagrams
Posted 02/04/2025. Antibiotic resistance is rising in Africa, but blood culture and sensitivity (BCS) testing faces challenges in Kenyan hospitals. A study using a complex systems approach across eight hospitals found that interconnected issues in both demand and supply, including cost, turnaround time, and logistical barriers undermine the use and sustainability of BCS testing at scale; targeted antimicrobial stewardship may offer a viable alternative. By Jacob McKnight & Mike English with KWTRP colleagues.
Through the eyes of the participant: using photovoice to understand the experiences and effects of ivermectin MDA in the context of the BOHEMIA clinical trial in Kwale, Kenya
Posted 27/03/2025. The photovoice sub-study in the BOHEMIA clinical trial let participants document their experiences and perceptions of the intervention. Their photos captured trial experiences, MDA effects and overlooked community concerns. This provided insights from participants' perspectives, highlighting issues beyond the study's scope that local health authorities and researchers might have missed. By Truphena Onyango
Treatment and treatment outcomes of snakebite envenoming in Uganda: a retrospective analysis
Posted 20/03/2025. Snakebite envenoming is a neglected tropical disease that causes significant morbidity and mortality in rural sub-Saharan Africa. While victims seek emergency care, documentation on their treatment remains limited. Stella Nanyonga and colleagues reviewed snakebite management in Uganda among 532 snakebite victims and found that only 6.9% of patients received snake antivenom.
Validating a web application’s use of genetic distance to determine helminth species boundaries and aid in identification
Posted 26/03/2025. Helminth species identification is challenging due to their diversity. Abigail Hui En Chan, Sompob Saralamba and their team developed ABIapp, a user-friendly R/Shiny application that helps researchers visualize taxonomic boundaries using genetic distance data. With up to 76% accuracy, ABIapp outperforms existing web-based tools, providing a valuable resource for helminth research.
Multiple insecticide resistance in Anopheles funestus from Mopeia, Central Mozambique
Posted 25/03/2025. Malaria vectors in Mopeia, Mozambique were found resistant to all classes of insecticides used in malaria control. New insecticide classes or non-insecticide-based tools are urgently needed. Resistance markers to dieldrin suggest potential selective pressure by agricultural pesticides. Coordinated and rational insecticide usage between health and agriculture sectors is needed. By Marta Maia.
Comparing HemoCue® and Quantitative Buffy Coat® and Coulter Counter-measured haemoglobin concentrations in African children with acute uncomplicated malaria: a Bland–Altman analysis
Posted 19/03/2025. Malaria studies often involve blood transfusion to severe malarial anaemic children. Accurate Anaemia diagnosis is crucial for effective management. Hence, important to determine the level of agreement among haemoglobin concentrations measurement methods. HemoCue® should be used with caution in settings where decisions about blood transfusions are made. By Mavuto Mukaka
Can solidarity in global health curb the next outbreak? A commentary on mpox
Posted 18/03/2025. Appeals to solidarity are common during disease outbreaks. Yet, what solidarity means and how it is practiced varies across contexts. Caesar Atuire and colleagues bring conceptual clarity by distinguishing between deep and responsive solidarity. They argue that global health needs deep solidarity to curb outbreaks like mpox and to ensure that responsive solidaristic appeals are effective.
Tracing epistemic injustice in global antimicrobial resistance research
Posted 14/03/2025. This commentary explores whether there is epistemic injustice in global antimicrobial resistance (AMR) research – who sets priorities, who produces knowledge, and which types of knowledge are valued. Prof Phaik Yeong Cheah and colleagues argue that epistemic injustice may have created blind spots in policy. Addressing this requires a commitment to diversity, equity, and inclusion.