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Oxford Centre for Tropical Medicine and Global Health
Single-step versus conventional injectable artesunate for severe malaria in children: an open label, non-inferiority randomized clinical trial, Democratic Republic of the Congo and United Republic of Tanzania
Posted 7/1/2026. In the Democratic Republic of the Congo and Tanzania, a randomized clinical trial led by Prof Marie Onyamboko, Dr Samwel Gesase, and Dr Caterina Fanello demonstrated that, in children with severe malaria, one-step injectable artesunate was quicker and cheaper to administer and had equivalent safety and efficacy compared with the conventional formulation.
Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria
Posted 29/09/2023. This large study on the pharmacokinetics of single low dose primaquine in young Ugandan and Congolese children will help the MORU team develop an optimal dose for children with falciparum malaria to block malaria transmission and contribute to malaria elimination, especially of resistant falciparum parasites. By Bob Taylor
Improving neonatal health in rural Africa: how much do we know about neonatal jaundice?
Posted 26/09/2023. In this pilot study, Caterina Fanello and colleagues evaluated the prevalence of neonatal hyperbilirubinemia and related neonatal and maternal risk factors in a semi-rural area of the Democratic Republic of Congo. They also explored knowledge and practices of expectant mothers regarding this condition. Ways forward to improve diagnosis and treatment in these settings are discussed.