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Oxford Centre for Tropical Medicine and Global Health

1 in 4 malaria patients in Africa receive suboptimal dose of antimalarial drugs

A new study estimates that nearly 1 in 4 people with P. falciparum malaria in Africa are at risk of receiving too low a dose of artemisinin combination therapies (ACTs), increasing the chance of treatment failure and the risk that malarial parasites develop resistance to the drug they were exposed to.

ISARIC awarded £4.5 million to tackle the global threat of epidemic infectious diseases

The International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) has been awarded £4.5 million to accelerate clinical research to prevent illness and deaths from epidemic infectious diseases. ISARIC is a world-wide, grass-roots consortium of clinical research networks, working together on epidemic infections such as pandemic influenza, Ebola, Lassa fever, and plague.

IHTM Ethics Lead wins 3.4 million euro Wellcome Discovery Award

Caesar Atuire, who is the Ethics Lead for IHTM and a philosopher and health ethicist from Ghana, has received 3.4 million euros over 5 years from the Wellcome Discovery Awards to fund a project on global solidarity. 'Moving beyond Solidarity Rhetoric in Global Health: Pluriversality and Actionable Tools.'

CTMGH X takeover by IHTM starts 4 June

Get ready! - the CTMGH X takeover begins on Tuesday 4 June and 8 IHTM students who are working around the world will be sharing their research placement experience.

Salmonella and antibiotic residues found in meat in Vietnam

Over two-thirds of meat samples from Ho Chi Minh City were found to contain Salmonella bacteria, according to a study by the Oxford University Clinical Research Unit (OUCRU). Researchers purchased 117 samples of chicken meat, beef and pork from retail sites in 2016-2017; 68.4% of those samples were found to contain Salmonella bacteria.

Oxford Vice-Chancellor Louise Richardson visits MORU and SMRU

MORU and SMRU were delighted and honoured to host the University of Oxford Vice-Chancellor Prof Louise Richardson and her party during her visit to Thailand on 1-4 September. Accompanying the Vice-Chancellor were Jeremy Woodall (Director of Development (Asia)), Frewyeni Kidane (Fundraiser for Southeast Asia), Cher Wu (Asia Development office) and Ed Gibbs (NDM Director of Finance and Operations).

OUCRU hosts BactiVac Network Meeting to drive global vaccine development

The 5th Annual BactiVac Network Meeting, co-hosted by the Oxford University Clinical Research Unit (OUCRU) and the Bacterial Vaccines Network, took place from 4-7 November 2024 in Ho Chi Minh City, Vietnam.

Celebrating women in ICT: connected girls, creating brighter futures

The International Girl’s in ICT day is commemorated to create awareness on the critical need for more girls and women in the ICT sector, encourage and inspire young girls to actively pursue careers in STEM as well as engage the community to promote collaboration through partnerships. Kathreen Wafula, an ICT Support Technician in Kilifi, joins a strong team of techies and is one of the 4 women in the department.

Clinical trials on hydroxychloroquine/ chloroquine in COVID-19. Statement in response to damaging recent events

On 4 June 2020, after a week of increasing scientific concern and scrutiny, first The Lancet, then a little over an hour later the New England Journal of Medicine, retracted studies that were based on inaccessible data, provided by the Surgisphere corporation. The studies have been extremely damaging to chloroquine and hydroxychloroquine COVID-19 clinical trials around the globe. Here is MORU’s statement in response to these events.

Tales of treatment, of modernity and tradition, and of global health crisis

The Antibiotics and Activity Spaces project is a survey of 4,800 villagers in Thailand and Lao PDR to better understand how people access healthcare and whether there are simple early warning indicators to detect 'problematic' antibiotic use. Marco J Haenssgen and colleagues recently hosted a photography exhibition in Bangkok on rare and vivid narratives of healing in Northern Thailand.

MORU TME brings water pumps to Laos villages

MORU’s Lao PDR targeted malaria elimination (TME) team recently installed 8 hand pumps to provide safe drinking water in 4 villages in Nong District, Savannakhet Province after villagers requested the pumps in return for participating in a TME project.

Major medical journals retract Covid-19 studies

On 4 June 2020, after a week of increasing scientific concern and scrutiny, first The Lancet, then the New England Journal of Medicine, retracted studies that were based on inaccessible data. The studies have been extremely damaging to chloroquine and hydroxychloroquine COVID-19 clinical trials around the globe. MORU researchers played a key role in bringing this scandal to light, whose consequences continue to play out.

The 'impossible' job of being a neonatal nurse

The provision of high-quality care to sick newborns presents challenges in any health system. International guidelines suggest that even for babies who do not require intensive care, there should be one nurse for every 2 – 4 sick babies. However, recent studies conducted in Nairobi show that one nurse takes care of between 20 – 40 newborns. In a recently published policy brief the KEMRI Wellcome Trust programme highlights the experience of nurses in Nairobi’s New Born Units.

Analysing malaria treatments in Africa: a comparison of the two front-line treatments

A statistical analysis of WWARN data from 4,214 participants across multiple study sites in Africa has been published in BMC Medicine. Results indicate that the local prevalence of resistance-associated markers should be considered when choosing a first-line drug to ensure optimal duration of protection.

Geospatial modelling study highlights Indian regions with treatment-resistant malaria parasites

An updated systematic search and review of published information from over 4,000 malaria samples has identified areas in central, eastern and north-eastern India where treatment-resistant malaria parasites could be more prevalent.

AfOx Visiting Fellows Program now open

Applications are now being accepted for the AfOx Visiting Fellows Programme. This 4-6 weeks fellowship aims to facilitate collaborations, as well as foster research and teaching excellence in African institutions an the University of Oxford. Applicants must be residents of an African country and hold an appointment in an academic or research institution in an African country. Deadline 11th March 2018.

Antibiotic resistance has claimed at least one million lives each year since 1990: GRAM

Landmark GRAM Project study of global AMR burden over time forecasts a sharp rise in deaths, with 39 million lives lost between now and 2050

IHTM at Brazil VERDE

IHTM's Dr Roger Nascimento travelled to Manaus for the Brazil VERDE.

The COVID-19 vaccine: do we know enough to end the pandemic?

Blog by Rima Shretta. Preliminary efficacy results from three vaccine candidates currently in Phase 3 trials have shown an efficacy of more than 90% against the development of symptomatic COVID-19. While these results are promising, all vaccines are in relatively early stages of testing. A comprehensive and transparent roadmap is urgently needed, to determine how limited doses of the first vaccines to be licensed will be distributed, together with which groups will initially be prioritized.

Antimalarial chemoprophylaxis for forest goers could help accelerate malaria elimination in Cambodia

Giving people antimalarials during and after visiting the forest reduced their risk of contracting malaria 6-fold, and could be the missing piece towards eliminating malaria in Asia-Pacific and South America, say Mahidol and Oxford University researchers in a study published in The Lancet Infectious Diseases.

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