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Today April 25 is World Malaria Day. We would like to highlight a malaria photography project by photographer Pearl Gan, in collaboration with OUCRU in Vietnam and EOCRU in Indonesia. Pearl's malaria project aims to bring visibility to the people and their malaria burden through her photographs of them and their environment. She hopes to humanise the faces of malaria and the malaria problem in the Asia-Pacific to audiences unfamiliar with it.
MSc in Health Service Improvement and Evaluation modules
The MSc in Health Service Improvement and Evaluation includes 6 modules taught between October and June. Your final dissertation will bring the content of all modules together and be submitted at the end of August.
MSc in Health Service Improvement and Evaluation
The MSc in Health Service Improvement and Evaluation (HSIE) is a full-time face-to-face course across one year of study. This unique MSc is led by the Health Systems Collaborative research group in collaboration with the Nuffield Department of Medicine’s Centre for Global Health Research at Oxford. This MSc is distinct from other global health or public health courses, providing you with theory alongside practical skills to implement health service improvement and evaluation in today’s complex healthcare and service environments.
John Muriuki: Iron and life-threatening infections
There is a complex relationship between iron deficiency and infection, particularly in iron-deficient children, as pathogens also require iron. Innovative randomisation studies suggest that infections - such as malaria - can cause iron deficiency. Novel African-specific genetic variants are associated with iron status, shedding light on the genetic basis of iron deficiency and infection susceptibility.
Bipin Adhikari: Community engagement for malaria elimination
Community engagement is important for ethical research, understanding community vulnerabilities and aligning priorities to bridge the gap between researchers and the communities they serve. MORU researchers focus on social aspects of infectious diseases, primarily malaria, with recent projects in Laos, Cambodia, Tanzania, and Bangladesh. Using a bottom-up approach helps addressing power imbalances for an authentic engagement.
Edwine Barasa: the KEMRI-Wellcome Trust Research Programme
The KEMRI Wellcome Trust Research Programme focuses on five key thematic areas: vaccines, pathogen biology, population health, clinical research and health systems. Their multidisciplinary approach informs policy and community needs. Impactful recent work spans COVID-19 response, malaria vaccines and clinical guidelines, with future plans addressing emerging global health challenges linked with climate change.
Edna Mutua: Antimicrobial resistance surveillance and governance
In our global fight against antimicrobial resistance, KWTRP is piloting a surveillance project where hospital samples are transfered to high-capacity laboratories for analysis, to inform patient treatment and policy planning. Mitigating AMR is crucial as it can be costly in lives, hospital stays and livelihoods. An equitable AMR mitigation needs to balance gains and harms for just outcomes.
Paul Turner: Improving data for infection management
The ACORN project gathers clinical, microbiology, and antibiotic use data from nine countries in Asia and Africa to understand the burden and impact of antibiotic resistance on patient treatment and outcomes. It aims to improve direct patient care, generate treatment guidelines, and inform interventions to combat antibiotic resistance globally, ensuring better antibiotics for all.
Claire Chewapreecha: Melioidosis genomics
Genetic investigations into melioidosis, profiling both bacteria and patients, help understand disease acquisition and outcomes. Furthermore, identifying prevalent harmful bacterial genes supports vaccine development, and the development of CRISPR-Cas-based tests responds to an urgent need for rapid diagnosis that can reduce the detection time to under three hours with higher sensitivity. Applications developed in resource-limited settings show improved global applicability and impact on patients’ outcomes.
Carlo Perrone: Improving scrub typhus detection and prevention
In northern Thailand, MORU researchers focus on scrub typhus, a disease transmitted by small bugs in rural environments. A simple diagnostic cartridge for rapid detection would avoid critical delays and issues of current antibody-based tests. If accessible in small hospitals, this improved diagnostics has the potential to save lives by providing timely treatment. Involving local communities is essential to address the endemic nature of scrub typhus in rural areas.
Stuart Blacksell: Risk-based approach to biosafety
In biosafety and biosecurity, the recent risk-based approach departs from a rigid one-size-fits-all model. Tailoring safety measures to pathogen and activity levels enhances flexibility, which is vital in resource-limited settings. Systematic reporting of lab incidents globally is lacking, hindering transparency and root cause analysis. Most accidents result from human or procedural errors, highlighting the need for investment in personnel training.
Direk Limmathurotsakul: AMR: local, national, global impact
To fight antimicrobial resistance, researchers at MORU utilise hospital data to assess global impact and guide interventions. By analysing data, they identify hospitals needing support which enables targeted interventions. Automation and simplification aid data utilization in low-middle-income countries. This approach, bridging implementation and epidemiological research, is crucial and has the potential to save many lives.
Nick White: Improving the treatment of infectious diseases
With nearly 50 years in malaria research and more recent focus on COVID-19, research at MORU led to more effective treatments. In COVID-19, trials debunked drugs like ivermectin or favipiravir, but validated remdesivir, molnupiravir and protease inhibitors. As malaria faces drug resistance, triple therapies offer hope. MORU research aims for tangible health impacts, with an approach applicable to other infectious diseases.
Naomi Waithira: Data, science and health
MORU Data Management focuses on tropical infectious diseases, gathering data from diverse sources like patient interviews, medical records and laboratory results. This data, stripped of identifying information, is organized for analysis. Past clinical data aids new insights, augmented by mathematical modelling and AI. MORU aims to improve healthcare by leveraging technology for accurate, impactful solutions.
IHTM Podcasts
The IHTM podcast series provides a platform to discuss and address some of the current challenges in global health, particularly in resource limited contexts. The series will draw on IHTM faculty, teachers and alumni, who are at the forefront of international health, and we hope the podcasts will appeal to a broad global health audience and in particular the populations and organisations with which IHTM alumni work.