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A recent WWARN individual patient meta-analysis has gathered 18 published and unpublished studies from Africa and Asia to explore the relationships between identified Kelch 13 mutant alleles and delayed parasite clearance. The study results show one P. falciparum specific mutant and 20 pfk13 propeller region mutant alleles are strongly associated with the slow clearance phenotype, including 15 mutations that have not been confirmed before. It was reassuring that no pfk13 alleles associated with slow parasite clearance were observed in the parasites from African studies gathered between 2000-2017.
Kevin Marsh
MSc IHTM Lecturers MSc IHTM steering committee Principal Investigators Research Scientists
Kevin Marsh - Professor of Tropical Medicine
Yoel Lubell
MSc IHTM Lecturers Principal Investigators Research Scientists
Yoel Lubell - Professor of Global Health
Susanna Dunachie
Principal Investigators Research Scientists
Susanna Dunachie - Professor of Infectious Diseases
Wirichada Pan-ngum
MSc IHTM Lecturers MSc MGH Lecturers Research Scientists
Wirichada Pan-ngum - Associate Professor
Richard Price
Principal Investigators Research Scientists
Richard Price - Professor of Tropical Medicine
Lorenz Von Seidlein
Principal Investigators Research Scientists
Lorenz Von Seidlein - Professor of Global Health
Trudie Lang
Principal Investigators Research Scientists
Trudie Lang - Professor of Global Health Research
Paul Newton
Principal Investigators Research Scientists
Paul Newton - Professor of Tropical Medicine
François Nosten
Principal Investigators Research Scientists
François Nosten - Professor in Tropical Medicine