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Oxford is at the forefront of teaching and research to help combat diseases affecting populations worldwide. Through its world-leading Centre for Tropical Medicine and Global Health (CTMGH), the University is working to find practical solutions to the problems these diseases cause. The centre conducts its research overseas in Africa and Asia, and across two sites in Oxford. The linked article shares three Oxford profiles.

Mamadu Camara

Susanna Dunachie

Proochista Ariana

Buddha Basnyat

Celine Caillet

Trudie Lang

Thuong Thuong Nguyen

Thomas Peto

Richard Price

Jeanne Salje

Sompob Saralamba

James Watson

Sreymom Pol

Janjira Thaipadungpanit

Richard Hoglund

Raph Hamers

Nattwut Ekapirat

Sazid Ibna Zaman

Jahirul Karim

Vicki Marsh

We gathered rich insights into child survival in Kenya by mapping patterns over 22 years

5 May 2021

Although improvements in child survival globally have been remarkable, 5.2 million children still died in 2019, over half of these in sub-Saharan Africa. A range of factors likely include disparities in childhood immunisations, supplements and breastfeeding practices, antenatal care, skilled birth attendants working in healthcare facilities. Kenya needs to prioritise its child care plans, based on localities and populations with the greatest need. Two KWTRP studies give granular insights into the situation in regions across Kenya.

Risks of serious adverse events following treatment for visceral leishmaniasis

30 March 2021

This large-scale systematic review and meta-analysis aimed to collate all reported serious adverse events in visceral leishmaniasis clinical trials and quantify the incidence of mortality during the first 30 days of therapy. The analyses, which included clinical data from more than 35,000 patients, found that mortality following treatment was an extremely rare event and serious adverse events following treatments were poorly reported.

World TB Day: Finding new ways to test children for tuberculosis

24 March 2021

Every year, over a million children fall ill with tuberculosis (TB) globally, and about a quarter die from this potentially preventable and curable disease. The main challenge remains the diagnosis of TB, especially in resource-constrained settings. We currently need to collect mucus from the lungs or liquid contents of the stomach, which must be collected in a hospital. Different ways to diagnosis TB in children are urgently needed, especially for those infected with HIV. An international collaboration is now conducting a large diagnostic study in Uganda to fill this gap. The study aims to detect TB bacteria in body fluids such as blood, urine, stool and saliva that are easier to collect.

The RECOVERY Trial: One year on

23 March 2021

The Randomised Evaluation of COVid-19 thERapY (RECOVERY) trial was officially launched on 23 March 2020. It is the world's largest COVID-19 drug trial. Thanks to the ground-breaking work of RECOVERY, clinicians treating patients hospitalised with severe COVID-19 now have two treatments that are known to improve survival.

Researchers call for access to Ivermectin for young children

19 March 2021

Millions of children weighing less than 15kg are currently denied access to Ivermectin treatment due to insufficient safety data being available to support a change to the current label indication. The WorldWide Antimalarial Resistance Network’s new meta-analysis provides evidence that supports removing this barrier and improving treatment equity.

Gender imbalance in visceral leishmaniasis clinical trials

17 March 2021

Researchers have found that despite an ongoing trend for a decreasing proportion of males being enrolled in antileishmanial therapeutic efficacy trials over time, there are still 1.8 times as many males as females involved in clinical trials. A new systematic review and meta-analysis suggests that existing knowledge on drug efficacy is derived from a study population that is heavily skewed towards adult males. At the same time, substantially less is known about the optimal treatment response in female patients.

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