Professor Guy Thwaites
Research groups
Guy Thwaites
Professor of Infectious Diseases
- Director of Oxford University Clinical Research Unit (OUCRU), Vietnam
OUCRU Vietnam
Guy Thwaites is an academic infectious diseases physician and clinical microbiologist. He has been Director of the Oxford University Clinical Research Unit/Wellcome Programme in Vietnam since October 2013. He is responsible for the scientific strategy of the programme, with its major research themes of emerging viral infections, dengue, brain infections, tuberculosis, malaria, enteric infections, antimicrobial drug resistance and care of the critically ill.
His personal research interests focus on severe bacterial infections, including meningitis and Staphylococcus aureus bloodstream infection, and tuberculosis. He has a longstanding research interest in the diagnosis, treatment and pathophysiology of tuberculous meningitis. Much of his research has been centred on large, pragmatic, randomized controlled trials which have addressed questions of key clinical importance, but have also provided the framework for providing unique insights into disease pathogenesis, antimicrobial pharmacology, and host and bacterial genetics.
Key publications
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Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial
Arjyal A. et al, (2016), The Lancet Infectious Diseases, 16, 535 - 545
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Intensified Antituberculosis Therapy in Adults with Tuberculous Meningitis
Heemskerk AD. et al, (2016), New England Journal of Medicine, 374, 124 - 134
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A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure
Pham Thanh D. et al, (2016), eLife, 5
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Optimum population-level use of artemisinin combination therapies: a modelling study
Nguyen TD. et al, (2015), The Lancet Global Health, 3, e758 - e766
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Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events
Wong VK. et al, (2015), Nature Genetics, 47, 632 - 639
Recent publications
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Severe paradoxical reaction in tuberculous meningitis.
Donovan J. et al, (2021), IDCases, 23
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Viral Metagenomic Analysis of Cerebrospinal Fluid from Patients with Acute Central Nervous System Infections of Unknown Origin, Vietnam.
Anh NT. et al, (2021), Emerging infectious diseases, 27, 205 - 213
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A novel method for measuring phenotypic colistin resistance in Escherichia coli populations from chicken flocks.
Nguyen NT. et al, (2020), Applied and environmental microbiology
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The Natural History and Transmission Potential of Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Van Vinh Chau N. et al, (2020), Clinical Infectious Diseases, 71, 2679 - 2687
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Azithromycin in Hospitalised Patients with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Horby PW. et al, (2020)