Professor Guy Thwaites
Podcast interview
Tuberculosis meningitis
Tuberculosis meningitis affects a fractions of TB patients but causes high levels of mortality and morbidity. A recent trial at OUCRU showed that aspirin can greatly improve outcomes. Such trial is typical of the work done in our Vietnam units, where all the research is focussed on improving the outcome for patients directly.
Research groups
Guy Thwaites
Professor of Infectious Diseases
- Director of Oxford University Clinical Research Unit (OUCRU), Vietnam
OUCRU Vietnam
Guy Thwaites is an academic infectious diseases physician and clinical microbiologist. He has been Director of the Oxford University Clinical Research Unit/Wellcome Programme in Vietnam since October 2013. He is responsible for the scientific strategy of the programme, with its major research themes of emerging viral infections, dengue, brain infections, tuberculosis, malaria, enteric infections, antimicrobial drug resistance and care of the critically ill.
His personal research interests focus on severe bacterial infections, including meningitis and Staphylococcus aureus bloodstream infection, and tuberculosis. He has a longstanding research interest in the diagnosis, treatment and pathophysiology of tuberculous meningitis. Much of his research has been centred on large, pragmatic, randomized controlled trials which have addressed questions of key clinical importance, but have also provided the framework for providing unique insights into disease pathogenesis, antimicrobial pharmacology, and host and bacterial genetics.
Recent publications
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Evolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia
Chung The H. et al, (2021), Communications Biology, 4
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Azithromycin and cefixime combination versus azithromycin alone for the out-patient treatment of clinically suspected or confirmed uncomplicated typhoid fever in South Asia: a randomised controlled trial protocol
Giri A. et al, (2021), Wellcome Open Research, 6, 207 - 207
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Effects of prophylactic and therapeutic antimicrobial uses in small-scale chicken flocks.
Van Cuong N. et al, (2021), Zoonoses and public health, 68, 483 - 492
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Cost-effectiveness of amphotericin B deoxycholate versus itraconazole for induction therapy of talaromycosis in HIV-infected adults in Vietnam
Buchanan J. et al, (2021), Open Forum Infectious Diseases
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Using syndromic measures of mortality to capture the dynamics of COVID-19 in Java, Indonesia, in the context of vaccination rollout.
Djaafara BA. et al, (2021), BMC medicine, 19