Professor Guy Thwaites
Podcast interview
Tuberculosis meningitis
Tuberculosis meningitis affects a fractions of TB patients but causes high levels of mortality and morbidity. A recent trial at OUCRU showed that aspirin can greatly improve outcomes. Such trial is typical of the work done in our Vietnam units, where all the research is focussed on improving the outcome for patients directly.
Research groups
Guy Thwaites
Professor of Infectious Diseases
- Director of Oxford University Clinical Research Unit (OUCRU), Vietnam
OUCRU Vietnam
Guy Thwaites is an academic infectious diseases physician and clinical microbiologist. He has been Director of the Oxford University Clinical Research Unit/Wellcome Programme in Vietnam since October 2013. He is responsible for the scientific strategy of the programme, with its major research themes of emerging viral infections, dengue, brain infections, tuberculosis, malaria, enteric infections, antimicrobial drug resistance and care of the critically ill.
His personal research interests focus on severe bacterial infections, including meningitis and Staphylococcus aureus bloodstream infection, and tuberculosis. He has a longstanding research interest in the diagnosis, treatment and pathophysiology of tuberculous meningitis. Much of his research has been centred on large, pragmatic, randomized controlled trials which have addressed questions of key clinical importance, but have also provided the framework for providing unique insights into disease pathogenesis, antimicrobial pharmacology, and host and bacterial genetics.
Recent publications
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Tuberculous meningitis: progress and remaining questions.
Huynh J. et al, (2022), Lancet Neurol, 21, 450 - 464
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Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis
Horby PW. et al, (2022)
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Clinical standards for the diagnosis, treatment and prevention of TB infection.
Migliori GB. et al, (2022), The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 26, 190 - 205
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REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis Risk.
Shah JA. et al, (2022), Journal of immunology (Baltimore, Md. : 1950)
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Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
Murray CJL. et al, (2022), The Lancet, 399, 629 - 655