Professor Guy Thwaites
Research groups
Guy Thwaites
Professor of Infectious Diseases
- Director of Oxford University Clinical Research Unit (OUCRU), Vietnam
OUCRU Vietnam
Guy Thwaites is an academic infectious diseases physician and clinical microbiologist. He has been Director of the Oxford University Clinical Research Unit/Wellcome Programme in Vietnam since October 2013. He is responsible for the scientific strategy of the programme, with its major research themes of emerging viral infections, dengue, brain infections, tuberculosis, malaria, enteric infections, antimicrobial drug resistance and care of the critically ill.
His personal research interests focus on severe bacterial infections, including meningitis and Staphylococcus aureus bloodstream infection, and tuberculosis. He has a longstanding research interest in the diagnosis, treatment and pathophysiology of tuberculous meningitis. Much of his research has been centred on large, pragmatic, randomized controlled trials which have addressed questions of key clinical importance, but have also provided the framework for providing unique insights into disease pathogenesis, antimicrobial pharmacology, and host and bacterial genetics.
Key publications
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Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial
Arjyal A. et al, (2016), The Lancet Infectious Diseases, 16, 535 - 545
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Intensified Antituberculosis Therapy in Adults with Tuberculous Meningitis
Heemskerk AD. et al, (2016), New England Journal of Medicine, 374, 124 - 134
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A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure
Pham Thanh D. et al, (2016), eLife, 5
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Optimum population-level use of artemisinin combination therapies: a modelling study
Nguyen TD. et al, (2015), The Lancet Global Health, 3, e758 - e766
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Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events
Wong VK. et al, (2015), Nature Genetics, 47, 632 - 639
Recent publications
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The design and statistical aspects of VIETNARMS: a strategic post-licensing trial of multiple oral direct-acting antiviral hepatitis C treatment strategies in Vietnam
McCabe L. et al, (2020), Trials, 21
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The CIPAZ study protocol: an open label randomised controlled trial of azithromycin versus ciprofloxacin for the treatment of children hospitalised with dysentery in Ho Chi Minh City, Vietnam
Darton TC. et al, (2020), Wellcome Open Research, 5, 214 - 214
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The direct-medical costs associated with interferon-based treatment for Hepatitis C in Vietnam
Nguyen HA. et al, (2020), Wellcome Open Research, 4, 129 - 129
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Clinical, etiological and epidemiological investigations of hand, foot and mouth disease in southern Vietnam during 2015 - 2018.
Nhan LNT. et al, (2020), PLoS neglected tropical diseases, 14
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Characterizing Antimicrobial Resistance in Chicken Pathogens: A Step towards Improved Antimicrobial Stewardship in Poultry Production in Vietnam.
Yen NTP. et al, (2020), Antibiotics (Basel, Switzerland), 9