Professor Guy Thwaites
Research groups
Guy Thwaites
Professor of Infectious Diseases
- Director of Oxford University Clinical Research Unit (OUCRU), Vietnam
OUCRU Vietnam
Guy Thwaites is an academic infectious diseases physician and clinical microbiologist. He has been Director of the Oxford University Clinical Research Unit/Wellcome Programme in Vietnam since October 2013. He is responsible for the scientific strategy of the programme, with its major research themes of emerging viral infections, dengue, brain infections, tuberculosis, malaria, enteric infections, antimicrobial drug resistance and care of the critically ill.
His personal research interests focus on severe bacterial infections, including meningitis and Staphylococcus aureus bloodstream infection, and tuberculosis. He has a longstanding research interest in the diagnosis, treatment and pathophysiology of tuberculous meningitis. Much of his research has been centred on large, pragmatic, randomized controlled trials which have addressed questions of key clinical importance, but have also provided the framework for providing unique insights into disease pathogenesis, antimicrobial pharmacology, and host and bacterial genetics.
Key publications
-
Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial
Arjyal A. et al, (2016), The Lancet Infectious Diseases, 16, 535 - 545
-
Intensified Antituberculosis Therapy in Adults with Tuberculous Meningitis
Heemskerk AD. et al, (2016), New England Journal of Medicine, 374, 124 - 134
-
A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure
Pham Thanh D. et al, (2016), eLife, 5
-
Optimum population-level use of artemisinin combination therapies: a modelling study
Nguyen TD. et al, (2015), The Lancet Global Health, 3, e758 - e766
-
Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events
Wong VK. et al, (2015), Nature Genetics, 47, 632 - 639
Recent publications
-
The design and statistical aspects of VIETNARMS: a strategic post-licensing trial of multiple oral direct-acting antiviral hepatitis C treatment strategies in Vietnam
McCabe L. et al, (2020), Trials, 21
-
Respiratory viruses in individuals with a high frequency of animal exposure in southern and highland Vietnam
Nguyen TTK. et al, (2020), Journal of Medical Virology, 92, 971 - 981
-
Investigator-initiated randomized controlled trials in infectious diseases: better value for money for registration trials of new antimicrobials.
Paul M. et al, (2020), Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
-
Superiority of a novel Mp1p antigen detection enzyme immunoassay compared to standard BACTEC blood culture in the diagnosis of talaromycosis
Thu NTM. et al, (2020), Clinical Infectious Diseases
-
SARS-CoV-2 and co-infections detection in nasopharyngeal throat swabs of COVID-19 patients by metagenomics.
Van Tan L. et al, (2020), The Journal of infection