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Oxford Centre for Tropical Medicine and Global Health
Vu Thi Lan Huong: Antimicrobial stewardship
At OUCRU Hanoi, we aim to control AMR by improving antibiotic use in hospitals through stewardship programs. Our interventions have successfully altered prescribing behaviours, but have been challenging due to limited microbiological data. Policy engagement is crucial to amplify our impact, ensuring findings are accessible for government decisions. Our goal is to mitigate resistance, enhance hospital safety, and improve patient outcomes.
Abhilasha Karkey: Infectious diseases in Nepal
The primary goal of OUCRU-Nepal is to improve public health in Nepal and South Asia, with focus on typhoid, antimicrobial resistance, and dengue increase linked with climate change. Over the recent years, the TCV typhoid vaccine trial emphasized the importance of regional collaboration and working with policymakers. OUCRU-Nepal has built strong hospital and community relationships, boosting global visibility and collaborations.
Agnes Gwela: Immune mechanisms in severe malnutrition
Research on malnutrition's impact on infection risk reveals a complex relationship, especially in LMICs. Studying immune cells like neutrophils allows us to better understand how malnutrition increases vulnerability to illness in malnourished children. Our goal is to inform guidelines, develop interventions, and improve clinical care to ensure every child survives and thrives beyond their fifth birthday.
Sam Kinyanjui: Building local research leadership in Africa
Over 25 years ago, research on malaria vaccine design underlined the lack of first-hand experience of the disease among scientists, and the necessity to build capacity in affected regions. In Kenya, training and support frameworks have empowered over 1,000 budding scientists since 2008, addressing the continent's research capacity gap with strategic partnerships.
MSc in Health Service Improvement and Evaluation modules
The MSc in Health Service Improvement and Evaluation includes 6 modules taught between October and June. Your final dissertation will bring the content of all modules together and be submitted at the end of August.
MSc in Health Service Improvement and Evaluation
The MSc in Health Service Improvement and Evaluation (HSIE) is a full-time face-to-face course across one year of study. This unique MSc is led by the Health Systems Collaborative research group in collaboration with the Nuffield Department of Medicine’s Centre for Global Health Research at Oxford. This MSc is distinct from other global health or public health courses, providing you with theory alongside practical skills to implement health service improvement and evaluation in today’s complex healthcare and service environments.
John Muriuki: Iron and life-threatening infections
There is a complex relationship between iron deficiency and infection, particularly in iron-deficient children, as pathogens also require iron. Innovative randomisation studies suggest that infections - such as malaria - can cause iron deficiency. Novel African-specific genetic variants are associated with iron status, shedding light on the genetic basis of iron deficiency and infection susceptibility.
Bipin Adhikari: Community engagement for malaria elimination
Community engagement is important for ethical research, understanding community vulnerabilities and aligning priorities to bridge the gap between researchers and the communities they serve. MORU researchers focus on social aspects of infectious diseases, primarily malaria, with recent projects in Laos, Cambodia, Tanzania, and Bangladesh. Using a bottom-up approach helps addressing power imbalances for an authentic engagement.
Edwine Barasa: the KEMRI-Wellcome Trust Research Programme
The KEMRI Wellcome Trust Research Programme focuses on five key thematic areas: vaccines, pathogen biology, population health, clinical research and health systems. Their multidisciplinary approach informs policy and community needs. Impactful recent work spans COVID-19 response, malaria vaccines and clinical guidelines, with future plans addressing emerging global health challenges linked with climate change.
Edna Mutua: Antimicrobial resistance surveillance and governance
In our global fight against antimicrobial resistance, KWTRP is piloting a surveillance project where hospital samples are transfered to high-capacity laboratories for analysis, to inform patient treatment and policy planning. Mitigating AMR is crucial as it can be costly in lives, hospital stays and livelihoods. An equitable AMR mitigation needs to balance gains and harms for just outcomes.
Paul Turner: Improving data for infection management
The ACORN project gathers clinical, microbiology, and antibiotic use data from nine countries in Asia and Africa to understand the burden and impact of antibiotic resistance on patient treatment and outcomes. It aims to improve direct patient care, generate treatment guidelines, and inform interventions to combat antibiotic resistance globally, ensuring better antibiotics for all.
Claire Chewapreecha: Melioidosis genomics
Genetic investigations into melioidosis, profiling both bacteria and patients, help understand disease acquisition and outcomes. Furthermore, identifying prevalent harmful bacterial genes supports vaccine development, and the development of CRISPR-Cas-based tests responds to an urgent need for rapid diagnosis that can reduce the detection time to under three hours with higher sensitivity. Applications developed in resource-limited settings show improved global applicability and impact on patients’ outcomes.
Carlo Perrone: Improving scrub typhus detection and prevention
In northern Thailand, MORU researchers focus on scrub typhus, a disease transmitted by small bugs in rural environments. A simple diagnostic cartridge for rapid detection would avoid critical delays and issues of current antibody-based tests. If accessible in small hospitals, this improved diagnostics has the potential to save lives by providing timely treatment. Involving local communities is essential to address the endemic nature of scrub typhus in rural areas.
Stuart Blacksell: Risk-based approach to biosafety
In biosafety and biosecurity, the recent risk-based approach departs from a rigid one-size-fits-all model. Tailoring safety measures to pathogen and activity levels enhances flexibility, which is vital in resource-limited settings. Systematic reporting of lab incidents globally is lacking, hindering transparency and root cause analysis. Most accidents result from human or procedural errors, highlighting the need for investment in personnel training.
Direk Limmathurotsakul: AMR: local, national, global impact
To fight antimicrobial resistance, researchers at MORU utilise hospital data to assess global impact and guide interventions. By analysing data, they identify hospitals needing support which enables targeted interventions. Automation and simplification aid data utilization in low-middle-income countries. This approach, bridging implementation and epidemiological research, is crucial and has the potential to save many lives.
Nick White: Improving the treatment of infectious diseases
With nearly 50 years in malaria research and more recent focus on COVID-19, research at MORU led to more effective treatments. In COVID-19, trials debunked drugs like ivermectin or favipiravir, but validated remdesivir, molnupiravir and protease inhibitors. As malaria faces drug resistance, triple therapies offer hope. MORU research aims for tangible health impacts, with an approach applicable to other infectious diseases.
Naomi Waithira: Data, science and health
MORU Data Management focuses on tropical infectious diseases, gathering data from diverse sources like patient interviews, medical records and laboratory results. This data, stripped of identifying information, is organized for analysis. Past clinical data aids new insights, augmented by mathematical modelling and AI. MORU aims to improve healthcare by leveraging technology for accurate, impactful solutions.