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Results of the Wellcome Trust funded trial of the experimental anti-Ebola drug TKM-130803 have been published today in PLOS Medicine. Using a novel approach designed to get rapid indications of a drug's effectiveness, the trial showed that at the dose given the drug did not improve survival compared to historic controls.
Congratulations 2021/22 MSc IHTM
MSc IHTM News
9 August 2022
The 2021/22 IHTM cohort gathered at Worcester College to celebrate the culmination of their MSc.
FORESFA and VIE project meetings
OCGHR
5 August 2022
The Medicine Quality Research Group organised a multidisciplinary hybrid meeting at Keble College, Oxford, July 3 to 6, for the FORESFA project ‘Forensic epidemiology and impact of substandard and falsified antimicrobials on public health’, funded by a Wellcome Collaborative Award.
MORU hepatitis work focusses on preventing mother-to-child transmission, high-at-risk populations, and remote communities
MOCRU MORU SMRU
28 July 2022
MORU Tropical Health Network researchers in Southeast Asia study various aspects of hepatitis B and C, infections that can lead to chronic liver diseases, and complications like liver cancer or cirrhosis. Researchers at MOCRU work on treatment for hepatitis C, a frequent opportunistic infection in HIV patients. MORU’s Clinical Pharmacology conducts two trials on possible treatments of hepatitis C. Hepatitis B is frequently transmitted from mother to child at birth, and SMRU researchers study mothers’ knowledge and behaviour, as well as prevention.
World Hepatitis Day: OUCRU research seeks to lower cost of treatment and improve access to care for patients with hepatitis C
OUCRU
28 July 2022
Today is World Hepatitis Day. OUCRU and hospitals in Ho Chi Minh City and Hanoi have been collaborating on hepatitis C clinical trials since 2018. Our research is centred around predictive factors for selecting persons who could be successfully treated with shorter durations of antiviral therapy. OUCRU’s social science and public engagement teams are currently working with underrepresented groups to create community-led strategies to link care and treatment for populations at risk for viral hepatitis. Our aim is to have a more significant impact on the treatment strategy and access to care for patients with hepatitis C in Vietnam and worldwide in the future.
Incomplete reporting of COVID-19 disease severity criteria compromises meta-analysis
MORU OCGHR
20 July 2022
Patients affected by COVID-19 should be treated according to the severity of their disease. However, not all key national or international organisations define severity in the same way. This imprecision in severity assessment compromises the validity of some therapeutic recommendations. Using individual patient data would better guide and improve therapeutic recommendations for COVID-19.
Quality of care, health workers’ well-being and COVID-19
KWTRP
19 July 2022
Nurses are central players in the provision of quality health care globally. Although neonatal units have not been at the epicenter of the current COVID-19 pandemic, challenges have also been raised for neonatal nurses. KWTRP share their COVID-19 related experiences and challenges, highlight strategies they used to manage the challenges and show how elements of the communication skills and emotional competence course helped them cope.
A multi-country study of monkeypox being launched – first cases enrolled in Geneva
OCGHR
12 July 2022
Researchers have launched a new study to improve our understanding of monkeypox disease. The first patients have now been recruited at Hôpitaux Universitaires de Genève (HUG) in Switzerland
Pandemic Sciences Institute formally launched in Oxford
OCGHR
6 July 2022
The University of Oxford’s Pandemic Sciences Institute (PSI) has been formally launched at a two-day event at the Blavatnik School of Government, at which the lead researchers set out its direction and strategy for the next five years.The PSI will draw together academics and experts from across the University to build a multi-disciplinary institute focused on reducing the risk from infectious threats through science, innovation and building global preparedness.
High prevalence of antibodies against COVID-19 within the general population: Evidence from Nairobi and Kilifi
KWTRP
5 July 2022
By May 2022, 69% of individuals residing within the Kilifi Health and Demographic System (HDSS) and 91% residing within the Nairobi Urban HDSS had evidence of an immune response to COVID-19 resulting from natural infection and/or vaccination, i.e., anti-spike IgG antibodies.
Prof Guy Thwaites co-authored WHO’s report on antibacterial agents in preclinical & clinical development
OUCRU
5 July 2022
OUCRU’s Director, Professor Guy Thwaites, has recently contributed to an analysis of antibacterial agents in preclinical and clinical development by the World Health Organisation (WHO), as part of the WHO advisory group on research and development of antibacterial treatments.
Field evaluation of EasyScan GO: a digital malaria microscopy device
MORU OCGHR SMRU
28 June 2022
Microscopic examination of Giemsa-stained blood films is key to quantifying and detecting malaria parasites but there can be difficulties in ensuring both a high-quality manual reading and inter-reader reliability. The EasyScan GO was developed as a potential solution to this, a microscopy device using machine-learning-based image analysis for automated parasite detection and quantification.
Dengue Research Article Awarded The 2021 – 2022 Alexandre Yersin Prize for Outstanding Publications
Awards & Appointments OUCRU
28 June 2022
OUCRU research article titled ‘Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes’ was recently awarded the 2021-2022 Alexandre Yersin Prize for Outstanding Publications.
Registration is open for The Global Health Network Conference 2022
Conferences & meetings OCGHR
24 June 2022
To tackle disease we need evidence to be generated through every type of health research study. This conference aims to bring together health research teams, organisations, health-workers, policy makers and practitioners to explore together how health research can be embedded into every healthcare setting. Join us at The Global Health Network Conference 2022 at the University of Cape Town, South Africa, 24 – 25 November 2022
OUCRU SPEAR Digital Diaries
EOCRU OUCRU OUCRU-Nepal Public Engagement
21 June 2022
Healthcare workers and community members in Indonesia, Nepal and Vietnam have been documenting their personal experiences of Covid-19. They have each made their own ‘digital diary’, using a range of creative tools and with technical support from the project team. These diaries form part of the SPEAR project: exploring the experiences and impacts of COVID-19 for healthcare workers and vulnerable communities.
The inside story of Recovery: how the world’s largest COVID-19 trial transformed treatment – and what it could do for other diseases
OCGHR
21 June 2022
Two years ago, the Recovery trial transformed the care of COVID patients with its dexamethasone announcement. Within four hours, the steroid was included in NHS treatment recommendations. Almost overnight, treatment of COVID patients around the world changed completely. It has been estimated that dexamethasone may have saved a million lives in the first nine months following the announcement. Recovery is a groundbreaking scientific machine which, from the outset, moved at unprecedented speed. In the first 100 days alone, the trial produced three groundbreaking results that would completely reshape COVID care.
Gail Carson chair of GOARN
Awards & Appointments OCGHR
21 June 2022
Dr Gail Carson from the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) is nominated chair of WHO Global Outbreak Alert & Response Network (GOARN)
Clinical trials for a malaria vaccine start in Mali and Indonesia
EOCRU OUCRU
21 June 2022
Sanaria Inc. announced that two new Phase 2 trials of its pioneering malaria vaccines have started. The first is in 6- to 10-year-old children living in Bancoumana, Mali, a malarious region of West Africa. The second is in Indonesian soldiers based in Sumatra, Indonesia. The soldiers will be deploying for six to nine months this coming August to an intensely malarious district in eastern Indonesia.
Enhanced vaccination against Japanese encephalitis virus could reduce encephalitis prevalence by one third in SE Asia
LOMWRU MORU
20 June 2022
Encephalitis is a worldwide public health issue, with a substantially high burden among children in Southeast Asia. A large study of the causes of childhood encephalitis in SE Asia suggests that enhanced and effective vaccination against the Japanese encephalitis virus alone could reduce encephalitis prevalence by one third.
Taking relationships seriously
KWTRP Public Engagement
17 June 2022
Community Engagement (CE) is a critical aspect of health research because of its potential to make research more ethical, relevant, and well implemented. Many research programmes now aim to incorporate CE activities at all stages of their work. This KWTRP brief summarises key findings from a malaria trials, and provides an illustration of how CE works more generally. It highlights facilitators and challenges to engagement, and the ethical issues that are particularly relevant in LMIC settings with under resourced health systems.
RECOVERY trial celebrates two-year anniversary of life-saving dexamethasone result
OCGHR
16 June 2022
Two years ago, the RECOVERY trial gave the world its first breakthrough against coronavirus: the discovery that an inexpensive steroid pill, dexamethasone, reduced deaths by up to a third from COVID-1. Within hours, the result was breaking news across the world and hospitals were adopting the drug into the standard care given to all patients with COVID-19. In the nine months following the discovery, dexamethasone saved an estimated one million lives worldwide.