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« Back to NewsChildren with acute malnutrition and malaria: the double burden that increases risk of treatment failure
13 March 2024
An analysis of over 11,000 falciparum malaria individual patient data sets has found that acutely malnourished children have a higher risk of reinfections and treatment failures, even when treated with recommended doses of artemisinin-based combination therapies, currently the best malaria treatment available. The malaria parasite clearance was also likely to be longer in these children.
New study uses isotope ratio mass spectrometry to analyse origins of falsified antimalarials
20 February 2024
New work from the Medicine Quality Group at IDDO and MORU pilots the use of stable isotope mass spectrometry to estimate where falsified antimalarials and their components come from. The study, published in Scientific Reports, is a collaboration between the Medicine Quality Research Group, LOMWRU, and MORU Bangkok, working with stable isotope scientists in Utah, USA.
Repurposed tests can detect falsified vaccines, study finds
16 February 2024
Researchers have found that widely available rapid diagnostic tests (RDTs), typically used for common infections, can be repurposed to detect substandard and falsified (SF) vaccines, a significant but overlooked issue in global public health. Preliminary data suggests RDTs could be utilized by international organizations and regulators to screen vaccine supply chains for falsified products. This innovative approach addresses the urgent need for affordable tools to combat the threat of SF vaccines.
GRAM study reveals rising antimicrobial resistance in enteric fever across 75 countries, affecting millions
15 February 2024
Findings reveal resistance patterns for a priority pathogen--also known as typhoid fever--with high mortality and morbidity in resource-constrained settings
Researchers identify potential diagnostic markers of Japanese encephalitis, a leading cause of brain infection in Asia
21 June 2023
Work by Oxford DPhil could pave way towards a rapid diagnostic test for a disease that puts millions at risk across Asia-Pacific
New antibiotic combination speeds recovery from severe scrub typhus, which infects 1 million people per year
1 March 2023
Treating patients ill with severe scrub typhus – a life-threatening infection that kills tens of thousands of people a year - with a combination of intravenous antibiotics doxycycline and azithromycin is significantly more effective than the current monotherapy of using either drug alone, say researchers in a study published in the New England Journal of Medicine (NEJM).
Pilot study detects diverse DNA in ingredients of falsified tablets
10 January 2023
A recent multidisciplinary pilot study, originating from LOMWRU and the Medicine Quality Research Group of IDDO and MORU, investigated whether bacterial, plant, fungal and animal DNA in the ingredients and from the environment (eDNA) could be detected from falsified (aka counterfeit) tablets.
Researchers call for antimicrobial resistance surveillance to be improved
20 December 2022
The number of studies reporting antimicrobial resistance (AMR) data has increased in Africa, South and South East Asia according to new research in the International Journal of Infectious Diseases.
Constant genetic surveillance necessary to keep multidrug-resistant malaria parasite strains in check, study finds
1 December 2022
Continually monitoring malaria parasite populations is necessary to prevent outbreaks of previously dormant multidrug-resistant malaria strains, say University of Oxford researchers. Multidrug-resistant malaria parasite strains can rapidly grow or collapse in response to public health policy changes, say the researchers in a study published today in The Lancet.
Bacterial infections linked to one in eight global deaths, according to GRAM study
22 November 2022
Data showing 7.7 million deaths from 33 bacterial infections can guide measures to strengthen health systems, particularly in low-income settings
Enhanced vaccination against Japanese encephalitis virus could reduce encephalitis prevalence by one third in SE Asia
20 June 2022
Encephalitis is a worldwide public health issue, with a substantially high burden among children in Southeast Asia. A large study of the causes of childhood encephalitis in SE Asia suggests that enhanced and effective vaccination against the Japanese encephalitis virus alone could reduce encephalitis prevalence by one third.
Laos’ first Pint of Science: warty newts, COVID, AI for Instagram, and more!
11 May 2022
Organised by a grass-root community of thousands of scientists across the world, Pint of Science 2022 allows researchers in 25 countries and over 800 cities to share their latest findings with lay folk in interesting, informal settings. Lao PDR joined the global Pint of Science family on Monday 9 May, when the first-ever Pint of Science Laos kicked off!
Lack of evidence is key barrier to using portable devices to detect poor quality medicines
11 October 2021
A series of papers which reviewed portable devices to detect poor quality medicines has concluded major gaps in scientific evidence remain a key barrier for regulators to implement surveillance systems using such devices.
FIEBRE Laos concludes recruitment
9 November 2020
Congratulations to everyone involved in contributing to FIEBRE’s success - the clinical and laboratory staff, hospital, participants and local communities. The team has continued working throughout the COVID-19 epidemic despite national restrictions which slowed down enrolment and limited field activities.
Congratulations new NDM professors
30 October 2020
The University of Oxford has awarded CTMGH two new Professors. Elisabeth Ashley - UK-trained physician who specialises in infectious diseases and medical microbiology & virology, and Director of the Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU) in Lao PDR since 2019, Liz is conferred the title of Professor of Tropical Medicine. Stuart Blacksell - Senior Research Scientist based at the Mahidol-Oxford Tropical Medicine Research Unit (MORU) in Thailand, Stuart is conferred the title of Professor of Tropical Microbiology.
Large scale systematic review details causes of non-malarial febrile illnesses globally and identifies research priorities
21 September 2020
A series of articles that set out to explore the global distribution of infections that cause non-malarial febrile illness has been published in BMC Medicine. The series brings together the results of large-scale systematic reviews of the causes of fever in Africa, Latin America, and Southern and South-Eastern Asia, and has helped identify major knowledge gaps, geographical differences, priority areas for diagnostics research and development, and enabled the most comprehensive systematic review of literature to date.
COPCOV Covid-19 study prepares to begin participant enrolment
23 April 2020
Less than a month after it was announced, the MORU-led COPCOV study has made quick progress and expects to begin enrolling participants by the end of April.
After MQPH 2018, new collaborations to fight substandard medicines
21 November 2018
Over 200 delegates travelled from more than 50 countries to attend the first ever conference on Medicine Quality and Public Health (MQPH 2018) in Oxford from 23-28 Sept. The conference, at Keble College, brought together experts in pharmacy, public health, chemistry, law, sociology, governance and ethics, from medicines regulatory authorities, academia, pharmaceutical industry, NGOs, and international organisations.
FIEBRE study kicks off; aims to reveal leading causes of fever and tackle AMR
16 March 2018
FIEBRE aims to design new evidence-based guidelines to manage fever, thereby ensuring that patients get drugs that give them the best chance of recovery, and thereby help stop the spread of antimicrobial resistance (AMR), a major global health problem.
Laos TME field tests new malaria RDTs
24 May 2017
24 May 2017, Bangkok – This April and May, the targeted malaria elimination (TME) study in Laos’ final prevalence survey evaluated new tools to detect asymptomatic malaria. These included new rapid diagnostic tests (RDTs) that may be similar in sensitivity to a PCR performed on dried blood spots and reading machines that fire a laser at RDTs and use a thermal camera to detect faint positive results that would be beyond the range of the human eye.
MORU TME brings water pumps to Laos villages
2 May 2017
MORU’s Lao PDR targeted malaria elimination (TME) team recently installed 8 hand pumps to provide safe drinking water in 4 villages in Nong District, Savannakhet Province after villagers requested the pumps in return for participating in a TME project.
Investment is key to tackling the ongoing threat of fake medicines
14 December 2016
Prof Paul Newton, Director of LOMWRU and Head of the Medicine Quality Group at the Infectious Diseases Data Observatory IDDO, explains the history of falsified medicines and highlights what needs to be done to avert a problem that threatens us all.
Café Scientifique holds first Vientiane session
3 August 2016
On Thur 21 July, the University of Health Sciences, Ministry of Health in collaboration with LOMWRU held the first Vientiane Science Café event in Laos. More than 50 students and staff of the Faculties of Medicine, Pharmacy, Dentistry, Nursing Sciences, Medical Technology, Basic Sciences, and Public Health attended the two hour-long event.