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A recent WWARN individual patient meta-analysis has gathered 18 published and unpublished studies from Africa and Asia to explore the relationships between identified Kelch 13 mutant alleles and delayed parasite clearance. The study results show one P. falciparum specific mutant and 20 pfk13 propeller region mutant alleles are strongly associated with the slow clearance phenotype, including 15 mutations that have not been confirmed before. It was reassuring that no pfk13 alleles associated with slow parasite clearance were observed in the parasites from African studies gathered between 2000-2017.
Peter Horby
MSc IHTM Lecturers Principal Investigators Research Scientists
FMedSci Peter Horby - Moh Family Foundation Professor of Emerging Infections and Global Health
Chris Paton
Principal Investigators Research Scientists
Chris Paton - Head of the Global Health Informatics Group
Susanna Dunachie
Principal Investigators Research Scientists
Susanna Dunachie - Professor of Infectious Diseases
François Nosten
Principal Investigators Research Scientists
François Nosten - Professor in Tropical Medicine
Anthony Scott
Principal Investigators Research Scientists
Anthony Scott - Visiting Professor of Vaccinology
Frank Smithuis
Principal Investigators Research Scientists
Frank Smithuis - Professor of Tropical Medicine
James Berkley
MSc IHTM Lecturers Principal Investigators Research Scientists
MBBS MTropMed MRCP MD FRCPCH FMedSci James Berkley - Professor of Paediatric Infectious Diseases
Stuart Blacksell
Principal Investigators Research Scientists
Stuart Blacksell - Professor of Tropical Microbiology
Arjen Dondorp
Principal Investigators Research Scientists
Arjen Dondorp - Professor of Tropical Medicine
Kevin Marsh
MSc IHTM Lecturers MSc IHTM steering committee Principal Investigators Research Scientists
Kevin Marsh - Professor of Tropical Medicine
Trudie Lang
Principal Investigators Research Scientists
Trudie Lang - Professor of Global Health Research
Nicholas Day
MSc IHTM steering committee Principal Investigators Research Scientists
MA BM BCh DM FRCP FMedSci Nicholas Day - Professor of Tropical Medicine