Professor Anthony Scott
Visiting Professor of Vaccinology
Invasive Bacterial Diseases
Anthony Scott is based in Kilifi, Kenya, where he leads a group focused on invasive bacterial diseases of children. His interests lie in the evaluation of vaccines, particularly against Hib and the pneumococcus; the epidemiology of invasive bacterial infections and their interaction with malaria: the transmission of Streptococcus pneumoniae among children in Kenya; host susceptibility to pneumococcal disease; the aetiology of pneumonia in children; and the social and epidemiological determinants of mortality in children. He is the co-director, with Tom Williams, of the Kilifi Health and Demographic Surveillance System (KHDSS), a population-based surveillance of vital events and migration among 250,000 people linked to morbidity surveillance Kilifi District Hospital.
Anthony works closely with the Ministry of Health in Kenya providing disease burden, vaccine effectiveness, and cost effectiveness data to inform vaccine policy decisions. Current vaccine trials involve (a) Phase I/II studies of a Whole Cell Vaccine against pneumococcus; (b) a Fractional dose study of PCV10 and PCV13 (c) An impact study to examine serotype replacement disease in the Kenyan national immunisation programme.
He is currently supervising Ph.D. students in the areas of pneumonia aetiology and management; epidemiology and modelling of invasive pneumococcal disease and the impact of vaccine; the epidemiology and transmission of non-typhoidal Salmonella.
Effect of Haemophilus influenzae type b vaccination without a booster dose on invasive H influenzae type b disease, nasopharyngeal carriage, and population immunity in Kilifi, Kenya: a 15-year regional surveillance study
Hammitt LL. et al, (2016), The Lancet Global Health, 4, e185 - e194
Burden of disease in adults admitted to hospital in a rural region of coastal Kenya: an analysis of data from linked clinical and demographic surveillance systems
Etyang AO. et al, (2014), The Lancet Global Health, 2, e216 - e224
Population effect of 10-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae and non-typeable Haemophilus influenzae in Kilifi, Kenya: findings from cross-sectional carriage studies
Hammitt LL. et al, (2014), The Lancet Global Health, 2, e397 - e405
Risk and causes of paediatric hospital-acquired bacteraemia in Kilifi District Hospital, Kenya: a prospective cohort study
Aiken AM. et al, (2011), The Lancet, 378, 2021 - 2027
Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study
Scott JAG. et al, (2011), The Lancet, 378, 1316 - 1323
Njuguna P. et al, (2019), BMC Medicine, 17
Salzberg NT. et al, (2019), Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 69, S262 - S273
Uyoga S. et al, (2019), The Lancet. Global health, 7, e1458 - e1466
Muriuki JM. et al, (2019), Science advances, 5
Kagia N. et al, (2019), Clinical Infectious Diseases, 69, 751 - 759