Professor Nicholas PJ Day
Podcast interview
MORU aims to fight the infectious tropical diseases affecting rural communities in Asia and elsewhere in the developing world. MORU's malaria research aims to directly improve the treatment of the disease globally. It's researchers focus on the treatment of severe malaria, the spread of antimalarial drug resistance, and the pathophysiology of falciparum and vivax malaria. These studies are used to formulate novel adjuvant therapies, and have been translated into recommendations for the use of artemisinin based combination therapies.
Research groups
Colleges
Nicholas Day
MA BM BCh DM FRCP FMedSci
Professor of Tropical Medicine
- Director of the Mahidol Oxford Tropical Medicine Research Unit, Thailand, and of the Wellcome Trust Thailand Asia and Africa Programme
MORU
Nick Day's interests include the epidemiology, diagnosis, pathophysiology, pathogen biology, treatment and prevention of malaria, rickettsial diseases including scrub typhus, melioidosis, leptospirosis, rickettsial infections, influenza, dengue and other communicable diseases afflicting rural populations throughout Asia and beyond. Cross-cutting interests include the drivers and epidemiology of AMR, and the syndromic management of febrile illnesses and sepsis in LMIC settings.
Key publications
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Genetic architecture of artemisinin-resistant Plasmodium falciparum
Miotto O. et al, (2015), Nature Genetics, 47, 226 - 234
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Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
Mok S. et al, (2015), Science, 347, 431 - 435
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Serosurveillance of Orientia tsutsugamushi and Rickettsia typhi in Bangladesh
Maude RR. et al, (2014), The American Journal of Tropical Medicine and Hygiene, 91, 580 - 583
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Ethics, Economics, and the Use of Primaquine to Reduce Falciparum Malaria Transmission in Asymptomatic Populations
Lubell Y. et al, (2014), PLoS Medicine, 11, e1001704 - e1001704
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Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Ashley EA. et al, (2014), New England Journal of Medicine, 371, 411 - 423
Recent publications
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Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project
Chandna A. et al, (2021), Wellcome Open Research, 6, 64 - 64
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Targeted capture and sequencing of Orientia tsutsugamushi genomes from chiggers and humans.
Elliott I. et al, (2021), Infect Genet Evol, 91
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An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples
Ahouidi A. et al, (2021), Wellcome Open Research, 6, 42 - 42
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Effectiveness of a sepsis programme in a resource-limited setting: a retrospective analysis of data of a prospective observational study (Ubon-sepsis).
Booraphun S. et al, (2021), BMJ Open, 11
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Antibiotic susceptibility of clinical Burkholderia pseudomallei isolates in northeast Thailand during 2015-2018 and the genomic characterization of β-lactam-resistant isolates.
Fen SHY. et al, (2021), Antimicrob Agents Chemother