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A systematic review analyses the results of 177 trials conducted between 1982 and 2016, including 18,436 patients who underwent electrocardiographic evaluation during malaria clinical trials. Nick White and colleagues found that serious cardiovascular side effects, which include sudden cardiac death, are very rare in the treatment of malaria with quinoline antimalarials. The work emphasises the importance of continued pharmacovigilance with the increasing use of quinoline antimalarials in mass treatment strategies such as intermittent preventative treatment and mass drug administration.
Andrew Maclachlan
MSc MGH Lecturers
Andrew Maclachlan - Associate Professor in Spatial Data Science and Visualisation
Arjen Dondorp
Principal Investigators Research Scientists
Arjen Dondorp - Professor of Tropical Medicine
Mehul Dhorda
Research Scientists
Mehul Dhorda - DeTACT-Africa Coordinator / Head of Specimen Management Laboratory
Trudie Lang
Principal Investigators Research Scientists
Trudie Lang - Professor of Global Health Research
François Nosten
Principal Investigators Research Scientists
François Nosten - Professor in Tropical Medicine
Richard Price
Principal Investigators Research Scientists
Richard Price - Professor of Tropical Medicine
Tri Wangrangsimakul
Graduate Students Research Scientists
BSc(hons) MB ChB DTM&H MRCP FRCPath Tri Wangrangsimakul - Research physician
Evelyne Kestelyn
MSc IHTM Lecturers Research Scientists
Evelyne Kestelyn - Head of the Clinical Trials Unit
Raph Hamers
Principal Investigators Research Scientists
MD PhD Raph Hamers - Associate Professor in Infectious Diseases
Rose McGready
MSc IHTM Lecturers Principal Investigators Research Scientists
Rose McGready - Professor of Tropical Maternal and Child Health
Ben Cooper
MSc MGH Lecturers Principal Investigators Research Scientists
Ben Cooper - Professor of Epidemiology
Mike English
MSc IHTM Lecturers MSc IHTM steering committee Principal Investigators Research Scientists
Mike English - Professor of International Child Health
George Warimwe
MSc IHTM Lecturers Principal Investigators Research Scientists
BVM PhD MRCVS George Warimwe - Professor of Vaccinology