Dr Mehul Dhorda
Contact information
Podcast interview
Research groups
Mehul Dhorda
Head of WWARN Asia Regional Centre
WWARN
Dr Mehul Dhorda is the Head of the Asia Regional Centre of WWARN and is based at the Mahidol-Oxford Tropical Medicine Research Unit (MORU) in Bangkok, Thailand. He works with his team at the Specimen Management Laboratory to support MORU-led projects by coordinating laboratory activities and quality assurance for study-related tests and assays. Of note are the UKAID-funded 'TRAC' study which tracked the spread of resistance of artemisinins and which has now been extended into the TRAC-II study aimed testing optimal drug combinations, including triple combinations, to treat multi-drug resistant malaria. Along with Professor Joel Tarning of MORU, he also helps to manage WWARN's Reference Material and Pharmacology Proficiency Testing programmes. He has been involved in the conception, development and implementation of projects aimed at monitoring the spread or emergence of resistance to antimalarials through simple protocols which can be implemented even in the most resource-poor settings. These innovative projects aim to make the results of the surveillance freely available through open access maps in near-real time. He is also leading multi-centric field studies to test a digital microscopy device for malaria parasite detection and quantification.
Key publications
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Numerical Distributions of Parasite Densities During Asymptomatic Malaria
Journal article
Imwong M. et al, (2016), Journal of Infectious Diseases, 213, 1322 - 1329
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Abundance of megalin and Dab2 is reduced in syncytiotrophoblast during placental malaria, which may contribute to low birth weight
Journal article
Lybbert J. et al, (2016), Scientific Reports, 6
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Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker
Journal article
Tun KM. et al, (2015), The Lancet Infectious Diseases, 15, 415 - 421
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Genetic architecture of artemisinin-resistant Plasmodium falciparum
Journal article
Miotto O. et al, (2015), Nature Genetics, 47, 226 - 234
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Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
Journal article
Mok S. et al, (2015), Science, 347, 431 - 435
Recent publications
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Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum.
Journal article
Bopp S. et al, (2018), Nature communications, 9
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A novel field-based molecular assay to detect validated artemisinin-resistant k13 mutants.
Journal article
Vachot-Ganée L. et al, (2018), Malaria journal, 17
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A Controlled Trial of Mass Drug Administration to Interrupt Transmission of Multi Drug Resistant Falciparum Malaria in Cambodian Villages.
Journal article
Tripura R. et al, (2018), Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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An inventory of supranational antimicrobial resistance surveillance networks involving low- and middle-income countries since 2000.
Journal article
Ashley EA. et al, (2018), The Journal of antimicrobial chemotherapy
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Submicroscopic Plasmodium prevalence in relation to malaria incidence in 20 villages in western Cambodia
Journal article
Tripura R. et al, (2017), Malaria Journal, 16