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A systematic review analyses the results of 177 trials conducted between 1982 and 2016, including 18,436 patients who underwent electrocardiographic evaluation during malaria clinical trials. Nick White and colleagues found that serious cardiovascular side effects, which include sudden cardiac death, are very rare in the treatment of malaria with quinoline antimalarials. The work emphasises the importance of continued pharmacovigilance with the increasing use of quinoline antimalarials in mass treatment strategies such as intermittent preventative treatment and mass drug administration.
Direk Limmathurotsakul
Research Scientists
Direk Limmathurotsakul - Professor of Infectious Disease Epidemiology
Susanna Dunachie
Principal Investigators Research Scientists
Susanna Dunachie - Professor of Infectious Diseases
Trudie Lang
Principal Investigators Research Scientists
Trudie Lang - Professor of Global Health Research
Paul Newton
Principal Investigators Research Scientists
Paul Newton - Professor of Tropical Medicine
Thuong Thuong Nguyen
Principal Investigators Research Scientists
Thuong Thuong Nguyen - Associate Professor
Wirichada Pan-ngum
MSc IHTM Lecturers MSc MGH Lecturers Research Scientists
Wirichada Pan-ngum - Associate Professor
Anthony Scott
Principal Investigators Research Scientists
Anthony Scott - Visiting Professor of Vaccinology
Joel Tarning
MSc MGH Lecturers Principal Investigators Research Scientists
Joel Tarning - Professor of Clinical Pharmacology
Chris Paton
Principal Investigators Research Scientists
Chris Paton - Head of the Global Health Informatics Group
Brian Angus
MSc IHTM Lecturers MSc IHTM steering committee Principal Investigators Research Scientists
BSc, MBChB, DTM&H, FRCP, MD, FFTM Brian Angus - Professor and Reader in Infectious Diseases