Professor Joel Tarning
Professor of Clinical Pharmacology
Joel Tarning is the head of the Clinical Pharmacology group focusing on bioanlytical method development, drug measurements in biological fluids and pharmacometric research. His research interest includes dose-optimisation using novel pharmacometric modelling approaches. His particular research interest includes antimalarial treatment in children and pregnant women.
The only way to determine accurately the correct dose regimens for antimalarial treatment is to establish a dose-response relationship through pharmacokinetic (PK) and pharmacodynamic (PD) modelling. Our research has shown that many of the antimalarial drugs developed in the past fifty years were introduced at the wrong dose, particularly in young children and pregnant women. This undoubtedly contributed to therapeutic failures and the development of drug-resistant parasites. Improving existing treatments and ensuring optimal dosing of the new drugs is essential for success in the control and elimination of malaria.
Joel Tarning received the biennial Giorgio Segré Prize from EUFEPS in 2014 for his research on the pharmacokinetic and pharmacodynamic properties of antimalarial drugs in vulnerable populations, such as pregnant women and young children.
Tarning J., (2016), New England Journal of Medicine, 374, 981 - 982
Bergstrand M. et al, (2014), Science Translational Medicine, 6, 260ra147 - 260ra147
Ashley EA. et al, (2014), New England Journal of Medicine, 371, 411 - 423
(2013), PLoS Medicine, 10, e1001564 - e1001564
Tarning J. et al, (2013), Antimicrobial Agents and Chemotherapy, 57, 5096 - 5103
McCabe L. et al, (2020), Trials, 21
White NJ. et al, (2020), PLOS Medicine, 17, e1003252 - e1003252
Horby P. et al, (2020)
Watson JA. et al, (2020), eLife, 9
Saito M. et al, (2020), BMC medicine, 18