In this review, Kevin Baird from EOCRU and Katherine Battle summarise evidence indicating that the global burden of malaria estimated from reported cases of acute attacks likely miss the widespread but more subtle harm done by chronic infection of P. vivax. Futhermore, P. vivax often affects impoverished communities where people face multiple health challenges. A recent study found that while P. falciparum is more likely to cause death within two weeks of diagnosis, patients with P. vivax were more than twice as likely to die over the long term. Chronic infections in people who are repeatedly exposed to P. vivax cause damage to the kidneys, brain, and circulatory system.
An improved understanding of the biology of P. vivax has recently revealed multiple factors that contribute to its toll on global health. The parasite can exist in the body at low levels that cause no symptoms, making it difficult to diagnose, but can still spread. Sub-Saharan Africa was once thought to be practically immune to P. vivax infection because most of the population lack the Duffy antigen, a molecule on the surface of red blood cells the parasite uses to invade. However, a recent study finds that P. vivax transmission is still widespread in this region. Additionally, there are two common genetic variations carried by part of the population that interfere with successful treatment of P. vivax malaria.
All these factors complicate efforts to estimate the full extent of P. vivax infections and control its spread. Baird and Battle conclude that the traditional approaches developed to combat P. falciparum in Africa are inadequate for P. vivax. Eliminating P. vivax will require different diagnostics, therapies and vector control strategies, and better data that reveal the true scope of the burden.
Read the publication 'The global burden of Plasmodium vivax malaria is obscure and insidious' on the PLOS Medicine website