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The efficacies of gatifloxacin and moxifloxacin were assessed in a BALB/c mouse model of pneumonic tularemia and compared with the efficacy of ciprofloxacin. The rate of relapse following dexamethasone treatment was also investigated. Mice were given 100 mg/kg of the antibiotic by oral administration twice daily for 14 days following an aerosol challenge. All three fluoroquinolones prevented disease during the treatment period, but significant failure rates occurred after the cessation of therapy. Both gatifloxacin and moxifloxacin were more effective than ciprofloxacin at reducing late mortality. Fluoroquinolones may therefore be considered useful candidates for the treatment of pneumonic tularemia.

Original publication

DOI

10.1016/j.ijantimicag.2006.02.006

Type

Journal

International journal of antimicrobial agents

Publication Date

05/2006

Volume

27

Pages

439 - 443

Addresses

DSTL Porton Down, Salisbury, Wiltshire SP4 OJQ, UK. jasteward@dstl.gov.uk

Keywords

Animals, Mice, Inbred BALB C, Mice, Tularemia, Pneumonia, Bacterial, Aza Compounds, Quinolines, Fluoroquinolones, Ciprofloxacin, Anti-Bacterial Agents, Female