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OBJECTIVES: To compare the fluoroquinolones gatifloxacin and moxifloxacin with ciprofloxacin for post-exposure prophylaxis of systemic anthrax in a BALB/c mouse model. METHODS: Treated mice and controls were inoculated subcutaneously with 5 x 10(4) spores/mouse of Bacillus anthracis Ames strain and observed for 37 days after challenge. Treated mice were given 100 mg/kg of antibiotic orally twice daily for 14 days, starting at various times post-challenge. RESULTS: Treatment starting 6 h post-challenge resulted in survival rates of 90%, 15% and 40% for gatifloxacin, moxifloxacin and ciprofloxacin, respectively. Treatment commencing 24 h post-challenge resulted in survival rates of 65%, 10% and 5%, respectively. Treatment starting more than 24 h after exposure had little effect on survival. CONCLUSIONS: Gatifloxacin appeared to be more effective than moxifloxacin or ciprofloxacin, at similar doses, for early post-exposure treatment of murine systemic anthrax. However, these results might be due to differences in potency or pharmacokinetic properties.

Original publication

DOI

10.1093/jac/dkh276

Type

Journal

The Journal of antimicrobial chemotherapy

Publication Date

07/2004

Volume

54

Pages

95 - 99

Addresses

Biomedical Sciences, Dstl Porton Down, Salisbury, Wiltshire SP4 OJQ, UK. jasteward@dstl.gov.uk

Keywords

Animals, Mice, Inbred BALB C, Mice, Bacillus anthracis, Anthrax, Aza Compounds, Quinolines, Fluoroquinolones, Ciprofloxacin, Anti-Infective Agents, Microbial Sensitivity Tests, Survival Analysis, Female