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AbstractISARIC (International Severe Acute Respiratory and emerging Infections Consortium) partnerships and outbreak preparedness initiatives enabled the rapid launch of standardised clinical data collection on COVID-19 in Jan 2020. Extensive global uptake of this resource has resulted in a large, standardised collection of comprehensive clinical data from hundreds of sites across dozens of countries. Data are analysed regularly and reported publicly to inform patient care and public health response. This report is a part of a series and includes the results of data analysis on 10 February 2021.We thank all of the data contributors for their ongoing support.Report highlights includeISARIC collaborators recorded symptoms from over 305,000 patients in hospital with COVID-19. The five most common symptoms at admission were cough, shortness of breath, history of fever, fatigue/malaise, and altered consciousness/confusion. Children and older adults were less likely to display typical symptoms, and around 40% of patients >80 years experienced confusion.The ISARIC international database continues to grow. Data have been entered for 305,241 individuals from 1736 sites across 64 countries.The analysis detailed in this report only includes individuals:for whom data collection commenced on or before 3 January 2021.ANDwho have laboratory-confirmed or clinically-diagnosed SARS-COV-2 infection.For the 240,149 cases who meet eligibility criteria for this report:The median age is 60 years.A total of 19% of patients were admitted at some point during their illness into an intensive care unit.Antibiotic use is high (80.7% of patients received antibiotics - the choice of antibiotic and specific indication have not yet been determined.)Cough, shortness of breath, history of fever, fatigue/malaise and altered consciousness/confusion were the most common symptoms at admission.Altered consciousness/confusion was also relatively frequent (24,477/109,690) and most common in elderly patients. Overall, elderly patients are less likely to present with URTI symptoms.To access previous versions of ISARIC COVID-19 Clinical Data Report please use the link below:https://isaric.org/research/covid-19-clinical-research-resources/evidence-reports/

Original publication

DOI

10.1101/2020.07.17.20155218

Type

Publisher

Cold Spring Harbor Laboratory

Publication Date

25/07/2020