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<i>Plasmodium malariae</i> is a neglected malaria parasite. It has wide geographic distribution and, although often associated with mild malaria, is linked to a high burden of anemia and nephrotic syndromes. Here, we report a cohort study conducted in the Kanchanaburi Province of Thailand during May 2013-June 2014 in which <i>P. malariae</i> infection was detected. Of the 812 study participants, two were found to be infected with <i>P. malariae</i>. One had an infection that led to acute malaria, but the other was positive for <i>P. malariae</i> at multiple visits during the study and apparently had chronic asymptomatic infection. Such persistent infection may explain how <i>P. malariae</i> has been able to thrive at very low prevalence and represents a challenge for malaria elimination.

Original publication





The American journal of tropical medicine and hygiene

Publication Date





1164 - 1169


Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.


Humans, Plasmodium malariae, Malaria, Prevalence, Cohort Studies, Endemic Diseases, Geography, Adult, Middle Aged, Myanmar, Thailand, Female, Male, Asymptomatic Infections, Indigenous Peoples