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Secondary bacterial pneumonia is a frequent complication of influenza, associated with high morbidity and mortality. We hypothesized that treatment with neutralizing influenza A antibody AT10_002 protects against severe secondary pneumococcal infection in a mouse model of influenza A infection. Influenza A (H3N2) virus-infected male C57Bl6 mice were treated intravenously with either AT10_002 or a control 2 days postinfection. Seven days later, both groups were infected with Streptococcus pneumoniae and killed 18 hours later. Mice receiving AT10_002 showed less loss of bodyweight compared with controls (+1% vs -12%, P 1 vs 2.5 × 105 colony-forming units per mg; P 

Original publication

DOI

10.1002/jmv.25212

Type

Journal

Journal of medical virology

Publication Date

09/2018

Volume

90

Pages

1431 - 1437

Addresses

Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands.

Keywords

Bronchoalveolar Lavage Fluid, Animals, Mice, Inbred C57BL, Humans, Streptococcus pneumoniae, Pneumonia, Pneumococcal, Disease Models, Animal, Body Weight, Immunologic Factors, Antibodies, Viral, Cytokines, Treatment Outcome, Immunization, Passive, Viral Load, Male, Influenza, Human, Influenza A Virus, H3N2 Subtype, Bacterial Load