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To assess the role of interleukin-1 (IL-1) in cutaneous leishmaniasis, Leishmania major-infected mice were treated with an anti-IL-1 receptor monoclonal antibody, LA-15.6. MoAb LA-15.6 prevents binding of IL-1 to both the T cell and B cell/macrophage forms of the IL-1 receptor. We found that treating with LA 15.6 inhibited the development of cutaneous lesions of L. major in both genetically-susceptible and resistant mice. Interestingly, this treatment had little or no effect on parasite numbers in the lesions or on the cytokines (interferon-gamma, interleukin-4) that the animals produced in response to infection with the parasite. These results suggest that although IL-1 plays a detrimental role in cutaneous leishmaniasis, it does not mediate this effect by altering the parasite-specific T cell response.

Original publication

DOI

10.1111/j.1365-3024.1994.tb00312.x

Type

Journal

Parasite immunology

Publication Date

11/1994

Volume

16

Pages

571 - 577

Addresses

Department of Tropical Public Health, Harvard School of Public Health, Boston, MA 02115.

Keywords

Lymph Nodes, Animals, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Leishmania major, Parasitemia, Leishmaniasis, Cutaneous, Disease Models, Animal, Receptors, Interleukin-1, Interleukin-1, Antibodies, Monoclonal, Cytokines, Lymphocyte Activation