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The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016-2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex.

Original publication

DOI

10.1038/s42003-022-03215-0

Type

Journal

Communications biology

Publication Date

28/03/2022

Volume

5

Addresses

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Keywords

Animals, Parasites, Plasmodium falciparum, Malaria, Falciparum, Artemisinins, Antimalarials, Drug Resistance