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We describe a family cluster of L. major that became infected by traveling to an endemic focus of CL, which did not respond to intralesional meglumine antimonial treatment whilst two were hospitalized due to the progressive disease that responded to 4 weeks of oral ketoconazole. Parasite genotyping of the internal transcribed spacer 1 gene revealed the same infecting parasite strain in all family members and was the same strain in GenBank that caused mucosal L. major in a tourist who visited several North African countries. We hypothesise a reduced host immune response in the two hospitalized patients.

Original publication

DOI

10.1016/j.ijmmb.2022.05.008

Type

Journal

Indian journal of medical microbiology

Publication Date

07/2022

Volume

40

Pages

451 - 454

Addresses

Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Keywords

Humans, Leishmania major, Leishmaniasis, Cutaneous, Meglumine, Organometallic Compounds, Antiprotozoal Agents, Meglumine Antimoniate