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Raman spectroscopy has recently undergone major advances in the area of deep non-invasive characterisation of biological tissues. The progress stems from the development of spatially offset Raman spectroscopy (SORS) and renaissance of transmission Raman spectroscopy permitting the assessment of diffusely scattering samples at depths several orders of magnitude deeper than possible with conventional Raman spectroscopy. Examples of emerging applications include non-invasive diagnosis of bone disease, cancer and monitoring of glucose levels. This article reviews this fast moving field focusing on recent developments within the medical area.

Original publication

DOI

10.1002/jbio.201200141

Type

Journal

Journal of biophotonics

Publication Date

01/2013

Volume

6

Pages

7 - 19

Addresses

Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, UK. Pavel.Matousek@stfc.ac.uk

Keywords

Bone and Bones, Animals, Humans, Neoplasms, Bone Diseases, Cadaver, Blood Glucose, Diagnostic Imaging, Spectrum Analysis, Raman, Equipment Design, Phantoms, Imaging, Light, Scattering, Radiation