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Systemic endectocidal drugs, used to control nematodes in humans and other vertebrates, can be toxic to Anopheles spp. mosquitoes when they take a blood meal from a host that has recently received one of these drugs. Recent laboratory and field studies have highlighted the potential of ivermectin to control malaria parasite transmission if this drug is distributed strategically and more often. There are important theoretical benefits to this strategy, as well as caveats. A better understanding of drug effects against vectors and malaria ecologies are needed. In the near future, ivermectin and other endectocides could serve as potent and novel malaria transmission control tools that are directly linked to the control of neglected tropical diseases in the same communities.

Original publication

DOI

10.1016/j.pt.2011.05.007

Type

Journal

Trends in parasitology

Publication Date

10/2011

Volume

27

Pages

423 - 428

Addresses

Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523-1692, USA. brian.foy@colostate.edu

Keywords

Animals, Humans, Anopheles, Plasmodium, Malaria, Ivermectin, Anthelmintics, Insecticides, Seasons, Disease Vectors, Mosquito Control, Drug Resistance, Female, Disease Transmission, Infectious