Poor Diagnostic Accuracy of Commercial Antibody-Based Assays for the Diagnosis of Acute Chikungunya Infection
Blacksell SD., Tanganuchitcharnchai A., Jarman RG., Gibbons RV., Paris DH., Bailey MS., Day NPJ., Premaratna R., Lalloo DG., de Silva HJ.
<jats:title>ABSTRACT</jats:title><jats:p>A Sri Lankan fever cohort (<jats:italic>n</jats:italic>= 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection.</jats:p>