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Long-acting cabotegravir plus rilpivirine has revolutionized the concept of antiretroviral therapy, but as the causes of virological failure and satisfaction can depend on patient background, real-world data are needed. In this single-center study, we reviewed clinical records of people with HIV (PWH) who received injectable cabotegravir plus rilpivirine between June 2022 and January 2023. We assessed virological and safety outcomes, including injection site reactions (ISRs) and changes in serum creatinine and cystatin C. Seventy-four patients were included. There were no virological failures. Approximately 80% of individuals achieved HIV-RNA undetectable in all visits up to 14 months (median 13 months) after switching. Pain upon injection was significantly more common at the rilpivirine injection site, while delayed pain was significantly more common at the cabotegravir injection site. The serum creatinine (mean difference -0.12 mg/dL, p 

Original publication





AIDS Res Hum Retroviruses

Publication Date





216 - 222


HIV, antiretroviral therapy, cabotegravir plus rilpivirine, injection site reaction, long-acting drug, Humans, HIV Infections, Anti-HIV Agents, Cystatin C, Injection Site Reaction, Creatinine, HIV-1, Anti-Retroviral Agents, Rilpivirine, Pain, Kidney, Asian People, Pyridones, Diketopiperazines