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The objective of this study was to investigate the impact of common mental disorder (CMD; depression/anxiety) symptoms and risky substance use in people with epilepsy in Ethiopia (four districts) on quality of life (QoL) and functioning over 6 months. A prospective cohort study was carried out. Multivariable linear regression followed by structural equation modelling (SEM) was employed. In the multivariable regression model, neither CMD symptoms (β coef. = -0.37, 95% confidence interval [CI] -1.30, +0.55) nor moderate to high risk of alcohol use (β coef. = -0.70, 95% CI -9.20, +7.81) were significantly associated with a change in QoL. In SEM, the summative effect of CMD on QoL was significant (B = -0.27, 95% CI -0.48, -0.056). Change in functional disability was not significantly associated with common mental disorder (CMD) symptoms (β coef. = -0.03, 95% CI -0.48, +0.54) or with moderate to high risk of alcohol use (β coef. = -1.31, 95% CI -5.89, 3.26). In the SEM model, functional disability was predicted by both CMD symptoms (B = 0.24, 95% CI 0.06, 0.41) and seizure frequency (B = 0.67, 95% CI 0.46, 0.87). In this rural Ethiopian setting, co-morbid CMD symptoms and seizure frequency independently predicted functional disability in people with epilepsy.

Original publication

DOI

10.1017/gmh.2025.24

Type

Journal

Global mental health (Cambridge, England)

Publication Date

01/2025

Volume

12

Addresses

Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.