Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children
Atkinson SH., Uyoga SM., Nyatichi E., Macharia AW., Nyutu G., Ndila C., Kwiatkowski DP., Rockett KA., Williams TN.
Key PointsEpistasis between the haptoglobin (Hp) common variants and α+thalassemia predicts the risk of severe malaria in Kenyan children. The inconsistent relationship between Hp type and malaria reported in previous studies may be explained by this epistatic interaction.