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BackgroundNovel influenza A viruses of avian-origin may be the precursors of pandemic strains. This descriptive study aims to introduce a novel avian-origin influenza A (H10N8) virus which can infect humans and cause severe diseases.MethodsCollecting clinical data of three cases of human infection with a novel reassortment avian influenza A (H10N8) virus in Nanchang, Jiangxi Province, China.ResultsThree cases of human infection with a new reassortment avian influenza A(H10N8) virus were described, of which two were fatal cases, and one was severe case. These cases presented with severe pneumonia that progressed to acute respiratory distress syndrome (ARDS) and intractable respiratory failure.ConclusionThis novel reassortment avian influenza A (H10N8) virus in China resulted in fatal human infections, and should be added to concerns in clinical practice.



Chinese medical journal

Publication Date





3238 - 3242


Nanchang University First Affiliated Hospital, Nanchang, Jiangxi 330006, China.


Humans, Imipenem, Fluoroquinolones, Antiviral Agents, Aged, Middle Aged, Female, Male, Influenza, Human, Oseltamivir, Influenza A Virus, H10N8 Subtype, Moxifloxacin