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<jats:title>SUMMARY</jats:title><jats:p>Porcine reproductive and respiratory syndrome (PRRS) outbreaks in pigs are associated with increased susceptibility of pigs to secondary bacterial infections, including <jats:italic>Streptococcus suis</jats:italic> – an important zoonotic pathogen causing bacterial meningitis in humans. This case-control study examined the association between human <jats:italic>S. suis</jats:italic> infection and PRRS outbreaks in pigs in northern Vietnam. We included 90 <jats:italic>S. suis</jats:italic> case-patients and 183 non-<jats:italic>S. suis</jats:italic> sepsis controls from a referral hospital in Hanoi in 2010, a period of major PRRS epizootics in Vietnam. PRRS exposure was determined using data from the National Centre of Veterinary Diagnosis. By univariate analysis, significantly more <jats:italic>S. suis</jats:italic> patients were reported residing in or adjacent to a PRRS district compared to controls [odds ratio (OR) 2·82, 95% confidence interval (CI) 1·35–5·89 and OR 3·15, 95% CI 1·62–6·15, respectively]. Only residency in adjacent districts remained significantly associated with risk of <jats:italic>S. suis</jats:italic> infection after adjusting for sex, occupation, and eating practices. SaTScan analysis showed a possible cluster of <jats:italic>S. suis</jats:italic> infection in humans around PRRS confirmed locations during the March–August period. The findings indicate an epidemiological association between PRRS in pigs and <jats:italic>S. suis</jats:italic> infections in humans. Effective strategies to strengthen control of PRRS in pigs may help reduce transmission of <jats:italic>S. suis</jats:italic> infection to humans.</jats:p>

Original publication





Epidemiology and Infection


Cambridge University Press (CUP)

Publication Date





35 - 44