Clinical and in vitro phenotype profiles of artemisinin-resistant Plasmodium falciparum K13 mutant alleles at the Thailand-Myanmar border
Nosten F., Boullé M., Witkowski B., Duru V., Sripawat K., Nair SK., McDew-White M., Anderson TJC., Phyo AP., Menard D.
Plasmodium falciparum artemisinin resistance (ART-R) may have evolved independently in various areas of the Greater Mekong Sub-region (1, 2), prompting the World Health Organization to change its regional policy from containment to elimination (3). Risks associated with ART-R include compromised use of artemisinin combined therapy (ACT), partner drug resistance selection, total ART-R resistance and geographical extension to other malaria endemic regions (2, 3). We therefore need to characterize ART-R in each independent setting and rapidly update the list of ART-R makers.