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<jats:p>The <jats:italic>w</jats:italic>Mel strain of <jats:italic>Wolbachia</jats:italic> can reduce the permissiveness of <jats:italic>Aedes aegypti</jats:italic> mosquitoes to disseminated arboviral infections. Here, we report that <jats:italic>w</jats:italic>Mel-infected <jats:italic>Ae. aegypti</jats:italic> (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The <jats:italic>w</jats:italic>Mel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals. This is explained by an increased susceptibility of field-reared wild-type mosquitoes to infection than laboratory-reared counterparts. Collectively, these field- and clinically relevant findings support the continued careful field-testing of <jats:italic>w</jats:italic>Mel introgression for the biocontrol of <jats:italic>Ae. aegypti</jats:italic>-born arboviruses.</jats:p>

Original publication





Proceedings of the National Academy of Sciences


Proceedings of the National Academy of Sciences

Publication Date





361 - 366