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The aim of this study was to test whether survival for patients with high-grade non-Hodgkin's lymphoma (NHL) can be improved with a non-cross-resistant regimen as compared to a CHOP-based regimen. This is a multicentre study comprising 325 adult patients, median age 58 years, with high-grade non-Hodgkin's lymphoma: patients of any age and performance status were eligible provided they were able to receive the drugs in the regimens. Patients were randomised to either B-CHOP-M (bleomycin, cyclophosphamide, doxorubicin, vincristine, prednisolone and methotrexate) or PEEC-M (methylprednisolone, vindesine, etoposide, chlorambucil and methotrexate) alternating with B-CHOP-M. At a median follow-up of 9 years, there was no significant difference in overall survival or disease-free survival between the two arms. Toxicities for the two regimens were equivalent. This study confirms that for relatively unselected patients with high-grade non-Hodgkin's lymphoma, an alternating multidrug regimen does not improve upon the results obtained with B-CHOP-M.

Original publication





European journal of cancer (Oxford, England : 1990)

Publication Date





1195 - 1201


Department of Clinical Oncology, Western General Hospital, Edinburgh, U.K.


Humans, Lymphoma, Non-Hodgkin, Chlorambucil, Cyclophosphamide, Vincristine, Vindesine, Methotrexate, Doxorubicin, Etoposide, Prednisolone, Methylprednisolone, Bleomycin, Antineoplastic Combined Chemotherapy Protocols, Disease-Free Survival, Drug Administration Schedule, Survival Rate, Follow-Up Studies, Adult, Aged, Middle Aged