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Tuberculosis is the primary infectious disease killer worldwide, with a growing threat from multidrug-resistant cases. Unfortunately, classic growth-based phenotypic drug susceptibility testing (DST) remains difficult, costly, and time consuming, while current rapid molecular testing options are limited by the diversity of antimicrobial-resistant genotypes that can be detected at once. Next-generation sequencing (NGS) offers the opportunity for rapid, comprehensive DST without the time or cost burden of phenotypic tests and can provide useful information for global surveillance. As access to NGS expands, it will be important to ensure that results are communicated clearly, consistent, comparable between laboratories, and associated with clear guidance on clinical interpretation of results. In this viewpoint article, we summarize 2 expert workshops regarding a standardized report format, focusing on relevant variables, terminology, and required minimal elements for clinical and laboratory reports with a proposed standardized template for clinical reporting NGS results for Mycobacterium tuberculosis.

Original publication





Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Publication Date





1631 - 1633


Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland.


Humans, Mycobacterium tuberculosis, Tuberculosis, Multidrug-Resistant, Antitubercular Agents, Microbial Sensitivity Tests, Sequence Analysis, DNA, Drug Resistance, Multiple, Bacterial, Genotype, Mutation, High-Throughput Nucleotide Sequencing