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Tularemia is an infection caused by Francisella tularensis with a worldwide distribution and diverse clinical manifestations. Limitations in both culture and serologic testing have led to substantial research into new diagnostic techniques and their clinical application, with PCR testing as the best example. This review focuses on the utility of culture, PCR and serologic testing for tularemia. In addition, we also review the evidence to support different therapeutic options for tularemia, highlighting both the most effective supporting evidence for therapeutic recommendations as well as gaps in current knowledge. We conclude the article with suggestions regarding potential areas for future research.

Original publication

DOI

10.1586/14787210.6.2.231

Type

Journal

Expert review of anti-infective therapy

Publication Date

04/2008

Volume

6

Pages

231 - 240

Addresses

United States Army, Defence Science and Technology Laboratory, Porton Down, UK. matthew.hepburn@amedd.army.mil

Keywords

Humans, Tularemia, Anti-Bacterial Agents, Serologic Tests, Bacteriological Techniques, Polymerase Chain Reaction