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Immune response to two different dosing schedules of the anthrax vaccine precipitated (AVP) vaccine.

Hepburn MJ., Hugh Dyson E., Simpson AJH., Brenneman KE., Bailey N., Wilkinson L., Hornby R., Mateczun AJ., Bell MG., Baillie LWJ.

A pilot study compared the immune response of regular (0, 3, 6, 32 weeks) and extended (0, 10, 13, 32 weeks) schedules of the UK anthrax vaccine (anthrax vaccine precipitated, AVP). Concentrations of antibodies to protective antigen (PA) were higher (p<0.05) among recipients of the extended (n=7) versus regular schedule (n=6) at week 32, and 2 weeks after the second and third vaccinations. Toxin neutralisation assay levels and anti-lethal factor antibodies followed patterns similar to anti-PA antibodies. Extending the interval between the first two AVP vaccinations may produce a stronger immune response, but persistence of this effect needs further study.

More information Original publication

DOI

10.1016/j.vaccine.2007.05.018

Type

Journal article

Publication Date

2007-08-01T00:00:00+00:00

Volume

25

Pages

6089 - 6097

Total pages

8

Addresses

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Keywords

Humans, Anthrax, Anthrax Vaccines, Antibodies, Bacterial, Neutralization Tests, Dose-Response Relationship, Immunologic, Adult, Middle Aged, Female, Male, Chemical Precipitation