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A pilot study compared the immune response of regular (0, 3, 6, 32 weeks) and extended (0, 10, 13, 32 weeks) schedules of the UK anthrax vaccine (anthrax vaccine precipitated, AVP). Concentrations of antibodies to protective antigen (PA) were higher (p<0.05) among recipients of the extended (n=7) versus regular schedule (n=6) at week 32, and 2 weeks after the second and third vaccinations. Toxin neutralisation assay levels and anti-lethal factor antibodies followed patterns similar to anti-PA antibodies. Extending the interval between the first two AVP vaccinations may produce a stronger immune response, but persistence of this effect needs further study.

Original publication

DOI

10.1016/j.vaccine.2007.05.018

Type

Journal

Vaccine

Publication Date

08/2007

Volume

25

Pages

6089 - 6097

Addresses

Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Wiltshire, United Kingdom. mjhepburn@mail.dstl.gov.uk

Keywords

Humans, Anthrax, Anthrax Vaccines, Antibodies, Bacterial, Neutralization Tests, Dose-Response Relationship, Immunologic, Adult, Middle Aged, Female, Male, Chemical Precipitation