Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The prophylactic potential of the azalide azithromycin as well as the fluoroquinolones trovafloxacin and grepafloxacin was assessed for the control of infection with Brucella melitensis in an experimental mouse model, determined by reduction in splenic bacterial burden. Trovafloxacin showed limited protective efficacy when administered 2h following a low-dose B. melitensis challenge, whereas grepafloxacin was ineffective. In comparison, azithromycin provided significant control of infection both following low- and high-dose challenges. Overall, the data confirm the potential utility of azithromycin in the prophylaxis of brucellosis and suggest that neither trovafloxacin nor grepafloxacin would likely be valuable for post-exposure prophylaxis of Brucella infection.

Original publication

DOI

10.1016/j.ijantimicag.2009.10.003

Type

Journal

International journal of antimicrobial agents

Publication Date

07/2010

Volume

36

Pages

66 - 68

Addresses

Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK. hsatkins@dstl.gov.uk

Keywords

Spleen, Animals, Mice, Inbred BALB C, Humans, Mice, Brucella melitensis, Brucellosis, Disease Models, Animal, Azithromycin, Piperazines, Naphthyridines, Fluoroquinolones, Anti-Bacterial Agents, Antibiotic Prophylaxis, Colony Count, Microbial, Female