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We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

Original publication

DOI

10.1038/ng1571

Type

Journal

Nature genetics

Publication Date

06/2005

Volume

37

Pages

590 - 592

Addresses

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

Keywords

Humans, Carcinoma, Ductal, Breast, Breast Neoplasms, Protein Kinases, DNA Mutational Analysis, Mutation, Multigene Family, Aged, Female