Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications
Sara Saheb Kashaf (cohort 2016-17), Grissel Trujillo-de Santiago, Roholah Sharifi, Kan Yue, Ehsan Shrizaei Sani, Mario Moisés Alvarez, Jeroen Leijten, Ali Khademhosseini , Reza Dana, Nasim Annabi
Closure of ocular wounds after an accident or surgery is typically performed by suturing, which is associated with numerous potential complications. This review covers two main classes of ocular adhesives: (1) synthetic adhesives based on cyanoacrylates, polyethylene glycol (PEG), and other synthetic polymers, and (2) adhesives based on naturally derived polymers, such as proteins and polysaccharides. In addition, different technologies to cover and protect ocular wounds such as contact bandage lenses, contact lenses coupled with novel technologies, and decellularized corneas are discussed. Continued advances in this area can help improve both patient satisfaction and clinical outcomes.