Performance of diagnostic and predictive host blood transcriptomic signatures for Tuberculosis disease: A systematic review and meta-analysis
Simon Mendelsohn (cohort 2015-16), Humphrey Mulenga, Chambrez-Zita Zauchenberger, Erick W. Bunyasi, Stanley Kimbung Mbandi, Benjamin Kagina, Adam Penn-Nicholson, Thomas J. Scriba , Mark Hatherill
Host blood transcriptomic biomarkers have potential as rapid point-of-care triage, diagnostic, and predictive tests for Tuberculosis disease. We aimed to summarise the performance of host blood transcriptomic signatures for diagnosis of and prediction of progression to Tuberculosis disease; and compare their performance to the recommended World Health Organisation target product profile.