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Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature, RISK6, for multiple applications: identifying individuals at risk of incident disease, as a screening test for subclinical or clinical tuberculosis, and for monitoring tuberculosis treatment. RISK6 utility was validated by blind prediction using quantitative real-time (qRT) PCR in seven independent cohorts.

More information Original publication

DOI

https://doi.org/10.1038/s41598-020-65043-8

Type

Alumni publications

Publisher

Nature

Publication Date

25/05/2020

Keywords

Diagnostic markers, Prognostic markers, Tuberculosis