The Application of Single-Cell RNA Sequencing in Vaccinology
Andrés Noé (cohort 2016-17), Tamsin N Cargill, Carolyn M Nielsen, Andrew J C Russell, Eleanor Barnes
Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell RNA sequencing offers various opportunities to decipher the immune response to infectious diseases and vaccines. Here, we describe the potential uses of single-cell RNA sequencing methods in prophylactic vaccine development, concentrating on infectious diseases including COVID-19.