Dr Charles Sande
Contact information
Research groups
Charles Sande
Research scientist
My research focusses on pneumonia and other serious respiratory infections that affect infants and young children. Pneumonia remains a major killer, particularly in the developing world, where the healthcare infrastructure necessary for managing the most serious manifestations of the disease are inadequate. Our group is particularly interested in understanding the mechanisms of disease caused by respiratory infections such as respiratory syncytial virus (RSV) and Streptococcus pneumoniae. To gain a complete understanding of the mechanisms of disease pathology, we use a coordinated systems biology approach to examine in fine detail the interactions between the immune systems of sick children and the pathogens that cause pneumonia. We use a broad array of tools including mass spectrometry-based proteomics, protein microarrays, bacterial metagenomics and RNA-seq transcriptomics to understand host-pathogen interactions in the respiratory tract. Using these techniques we are gaining new insights into the breadth of the infant response to infection and how these responses may be leveraged in the development of effective interventions against pneumonia in the future.
Recent publications
-
Priorities for developing respiratory syncytial virus vaccines in different target populations
Drysdale SB. et al, (2020), Science Translational Medicine, 12, eaax2466 - eaax2466
-
Vaccination against Respiratory Syncytial Virus.
Green CA. et al, (2020), Interdisciplinary topics in gerontology and geriatrics, 43, 182 - 192
-
Author Correction: Airway response to respiratory syncytial virus has incidental antibacterial effects.
Sande CJ. et al, (2019), Nature communications, 10
-
Airway response to respiratory syncytial virus has incidental antibacterial effects.
Sande CJ. et al, (2019), Nature communications, 10
-
Novel genetically-modified chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine safely boosts humoral and cellular immunity in healthy older adults.
Green CA. et al, (2019), The Journal of infection, 78, 382 - 392