Dr Cindy Chu
Cindy’s main research area is in Plasmodium vivax malaria. She has conducted studies on the epidemiology of P. vivax recurrence as well as efficacy trials with the schizonticidal agents chloroquine and dihydroartemisinin-piperaquine. Her current focus is on the radical curative treatment of P. vivax using 8-aminoquinolines and the haemolytic effects of this class of drugs in G6PD heterozygous females. The goal of this research is for the safe delivery of primaquine and tafenoquine for treatment of P. vivax malaria and within the context of P. vivax elimination.
SMRU free healthcare
Chloroquine and primaquine induced haematocrit changes to G6PD heterozygote
Plasmodium vivax recurrences
Primaquine-induced haemolysis in females heterozygous for G6PD deficiency
Chu CS. et al, (2018), Malaria Journal, 17
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria.
Llanos-Cuentas A. et al, (2019), The New England journal of medicine, 380, 229 - 241
Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria
Chu CS. et al, (2018), Clinical Infectious Diseases
Estimating the probable cause of recurrence in Plasmodium vivax malaria: relapse, reinfection or recrudescence?
Taylor A. et al, (2018)
Chloroquine Versus Dihydroartemisinin-Piperaquine With Standard High-dose Primaquine Given Either for 7 Days or 14 Days in Plasmodium vivax Malaria
Chu CS. et al, (2019), Clinical Infectious Diseases, 68, 1311 - 1319
Vivax malaria in pregnancy and lactation: a long way to health equity
Brummaier T. et al, (2020), Malaria Journal, 19
Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis.
Lee W-C. et al, (2020), eLife, 9
Declining Burden of Plasmodium vivax in a Population in Northwestern Thailand from 1995 to 2016 before Comprehensive Primaquine Prescription for Radical Cure
Chu CS. et al, (2020), The American Journal of Tropical Medicine and Hygiene, 102, 147 - 150
Optimizing G6PD testing for Plasmodium vivax case management: why sex, counseling, and community engagement matter.
Chu CS. et al, (2020), Wellcome open research, 5
Resolving the cause of recurrent Plasmodium vivax malaria probabilistically
Taylor AR. et al, (2019), Nature Communications, 10