Dr Cindy Chu
Cindy’s main research area is in Plasmodium vivax malaria. She has conducted studies on the epidemiology of P. vivax recurrence as well as efficacy trials with the schizonticidal agents chloroquine and dihydroartemisinin-piperaquine. Her current focus is on the radical curative treatment of P. vivax using 8-aminoquinolines and the haemolytic effects of this class of drugs in G6PD heterozygous females. The goal of this research is for the safe delivery of primaquine and tafenoquine for treatment of P. vivax malaria and within the context of P. vivax elimination.
SMRU free healthcare
Chloroquine and primaquine induced haematocrit changes to G6PD heterozygote
Plasmodium vivax recurrences
Primaquine-induced haemolysis in females heterozygous for G6PD deficiency
Chu CS. et al, (2018), Malaria Journal, 17
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria.
Llanos-Cuentas A. et al, (2019), The New England journal of medicine, 380, 229 - 241
Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria
Chu CS. et al, (2018), Clinical Infectious Diseases
Estimating the probable cause of recurrence in Plasmodium vivax malaria: relapse, reinfection or recrudescence?
Taylor A. et al, (2018)
Chloroquine Versus Dihydroartemisinin-Piperaquine With Standard High-dose Primaquine Given Either for 7 Days or 14 Days in Plasmodium vivax Malaria
Chu CS. et al, (2019), Clinical Infectious Diseases, 68, 1311 - 1319
Optimizing G6PD testing for Plasmodium vivax case management: why sex, counseling, and community engagement matter.
Chu CS. et al, (2020), Wellcome open research, 5
The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Commons RJ. et al, (2019), BMC Medicine, 17
The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis
Commons RJ. et al, (2019), PLOS Medicine, 16, e1002928 - e1002928
Tafenoquine and G6PD: a primer for clinicians.
Chu CS. and Freedman DO., (2019), Journal of travel medicine, 26
The impact of using primaquine without prior G6PD testing: a case series describing the obstacles to the medical management of haemolysis
Chu C. et al, (2019)