Le Thanh Hoang Nhat

My research focuses on integrating multi-omics—including genomics, transcriptomics, proteomics, and metabolomics—with imaging technologies (MRI/X-ray) to explore host immune responses in Tuberculous Meningitis (TBM) and Pulmonary Tuberculosis (PTB). This integrated approach aims to uncover the molecular mechanisms driving TB severity and develop novel prognostic and therapeutic strategies to improve patient outcomes.

In TBM, I am investigating the relationship between systemic and intracranial inflammation—captured through cerebrospinal fluid (CSF) multi-omics and MRI—and its correlation with disease severity and clinical outcomes. By identifying biomarkers of brain inflammation and damage, my research aim to develop novel interventions that modulate immune responses, with the goal of improving neurological recovery and reducing mortality.

In PTB, I am exploring how host immune responses, assessed through blood and sputum multi-omics, contribute to lung damage and bacterial clearance. My goal is to develop early diagnostic and prognostic tools using blood or sputum tests to classify disease severity, monitor treatment responses, and guide therapies targeting both bacterial eradication and lung protection.

Ultimately, my research is advancing host-directed therapies that enhance bacterial clearance, minimize organ damage, and improve clinical outcomes in TB, contributing to the future of TB treatment and expanding our understanding of TB pathogenesis.